CMAUP Plant Collective Molecular Activities

Plant Name: Phellodendron chinense

Taxonomic Information:

Plant ID: NPO22242
Plant Latin Name: Phellodendron chinense
Taxonomy Genus: Phellodendron
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 354508
Plant-of-the-World-Online: 774776-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Antibacterial; Bitter; Cholagogue; Diuretic; Expectorant; Hypoglycaemic; Ophthalmic; Skin; Stomachic; Vasodilator

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2B; DRD1; DRD2;
Hydrolase	ACHE;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Oxidoreductase	PTGS2; MAOA;
Unclassified	F3; SIGMAR1; THPO; LMNA; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP2D6; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	SIGMAR1	Sigma opioid receptor	Q99720	CHEMBL287
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.274E-11	2.708E-07	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.570E-10	2.488E-06	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	1.309E-09	4.749E-06	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS2
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.357E-08	2.954E-05	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	8.120E-08	7.940E-05	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.487E-07	1.295E-04	CYP1A2, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.876E-07	2.088E-04	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
BP	GO:0023052; signaling	GO:0050805; negative regulation of synaptic transmission	3.238E-07	2.275E-04	ACHE, DRD1, DRD2, PTGS2
CC	GO:0016020; membrane	GO:0031090; organelle membrane	4.740E-07	3.128E-04	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, FABP5, LMNA, MAOA, PTGS2, SIGMAR1
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	7.398E-07	4.738E-04	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, PTGS2, SIGMAR1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	8.942E-07	5.409E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.189E-06	7.000E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0042417; dopamine metabolic process	2.194E-06	1.190E-03	DRD1, DRD2, MAOA
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	2.459E-06	1.190E-03	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	2.459E-06	1.190E-03	CYP1A1, CYP3A4
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	3.098E-06	1.435E-03	CYP1A1, DRD2, LMNA, PPARA, PTGS2
BP	GO:0040011; locomotion	GO:0030334; regulation of cell migration	3.489E-06	1.519E-03	CYP1B1, DRD1, DRD2, F3, LMNA, MAPK1, PTGS2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.916E-06	1.845E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.916E-06	1.845E-03	CYP1A2, CYP3A4
BP	Unclassified;	GO:0021853; cerebral cortex GABAergic interneuron migration	8.188E-06	2.662E-03	DRD1, DRD2
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	8.188E-06	2.662E-03	CYP1A1, CYP3A4
BP	GO:0065007; biological regulation	GO:0008217; regulation of blood pressure	9.566E-06	2.777E-03	ADRA2B, DRD2, PPARA, PTGS2
BP	GO:0065007; biological regulation	GO:0048167; regulation of synaptic plasticity	1.090E-05	3.123E-03	DRD1, DRD2, MAPK1, PTGS2
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.228E-05	3.341E-03	CYP1A1, CYP3A4
BP	GO:0009987; cellular process	GO:1902533; positive regulation of intracellular signal transduction	1.635E-05	4.342E-03	ADRA2B, CYP1B1, DRD2, F3, MAPK1, PTGS2, THPO
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	1.718E-05	4.400E-03	CYP1A1, CYP2D6
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	1.971E-05	4.992E-03	ACHE, CYP1A1, DRD2, PPARA
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	2.289E-05	5.417E-03	CYP1A1, CYP1A2
BP	GO:0023052; signaling	GO:0051584; regulation of dopamine uptake involved in synaptic transmission	2.289E-05	5.417E-03	DRD1, DRD2
BP	GO:0032501; multicellular organismal process	GO:0007416; synapse assembly	3.577E-05	7.867E-03	ACHE, DRD1, DRD2
BP	GO:0032501; multicellular organismal process	GO:0030432; peristalsis	3.675E-05	7.955E-03	DRD1, DRD2
BP	GO:0032502; developmental process	GO:0021756; striatum development	4.489E-05	9.309E-03	DRD1, DRD2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.654E-09	5.342E-07	CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.112E-08	1.741E-06	MAOA, CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	8.412E-09	5.342E-07	CYP1A2, CYP1A1, CYP1B1, CYP3A4, PTGS2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.827E-07	9.721E-06	MAOA, CYP2D6, CYP1A2, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.890E-07	6.000E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.684E-06	5.681E-05	CYP2D6, MAOA, MAPK1, PTGS2
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.168E-05	1.855E-04	CYP1A1, CYP1B1, PTGS2
09160 Human Diseases	09164 Substance dependence	hsa05034	Alcoholism	1.721E-05	2.429E-04	MAOA, MAPK1, DRD1, DRD2
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	1.099E-05	1.855E-04	MAOA, DRD1, DRD2
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.609E-05	3.012E-04	MAPK1, DRD1, PPARA, DRD2
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.582E-05	3.012E-04	CYP1A2, CYP1A1, CYP3A4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	6.403E-05	6.777E-04	MAPK1, DRD1, DRD2
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	1.993E-04	1.947E-03	MAOA, DRD1, DRD2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.062E-04	2.777E-03	CYP1A2, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Hypotension	I95	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Idiopathic thrombocytopenic purpura	D69.3	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
NA: NA	Hyperaemia	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS2;
O00-O9A: Pregnancy, childbirth and the puerperium	Postpartum haemorrhage	O72	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperprolactinemia	E22.1	DRD2;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1; DRD2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; DRD2; MAOA; PTGS2;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	DRD2;
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
NA: NA	False perceptions	NA	DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
NA: NA	Corneal vascularity	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1; DRD2;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2;
NA: NA	Schizoaffective disorders	NA	DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PTGS2;
NA: NA	Rheumatold arthritis	NA	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2;
NA: NA	Itching	NA	DRD2;
NA: NA	Joint and muscular pain	NA	PTGS2;
K00-K95: Diseases of the digestive system	Gastrointestinal problems	K30-K31, Q40-Q41	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6; DRD2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychosis	F20-F29	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1; DRD2;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
NA: NA	Upper abdominal bloating	NA	ACHE;
NA: NA	Vomiting	NA	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Acromegaly	E22.0	DRD2;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	DRD2;
J00-J99: Diseases of the respiratory system	Nasal congestion	J34.89	DRD2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	DRD2; PTGS2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	DRD2; PTGS2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1; PTGS2;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PTGS2;
J00-J99: Diseases of the respiratory system	Asthma	J45	DRD2; PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADRA2B; MAOA; PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PTGS2;
NA: NA	Malignant essential hypertension	NA	DRD2;
NA: NA	Malignant phaeochromocytoma	NA	DRD2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	DRD2; PTGS2;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS2;
I00-I99: Diseases of the circulatory system	Pulmonary hypertension	I27.0, I27.2	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	DRD2; MAOA;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
I00-I99: Diseases of the circulatory system	Maintain blood pressure in hypotensive states	I10	DRD2;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	DRD2;
H00-H59: Diseases of the eye and adnexa	Ophthalmic disease	H00-H59	DRD2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2;
NA: NA	Peripheral vasoconstriction	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; DRD1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; DRD1; DRD2; MAOA;
C00-D49: Neoplasms	Pancreatic cancer	C25	PTGS2; F3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE; DRD1; DRD2; PTGS2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
K00-K95: Diseases of the digestive system	Dermal necrosis	K05	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Depressive fatigue	R53.82	DRD2;
NA: NA	Benign prostatic hypertrophy	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	DRD2;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; ACHE; DRD2; MAOA;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1; DRD2;
C00-D49: Neoplasms	Breast cancer	C50	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Carcinoid syndrome	E34.0	DRD2;
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	DRD2;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; MAPK1; PTGS2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Advanced stage Parkinson's disease	F02.3, G20	DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	DRD2;
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	DRD2;
I00-I99: Diseases of the circulatory system	Cardiotonic	I50	DRD2;
NA: NA	Inflammatory diseases	NA	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2B; DRD2; MAOA;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PTGS2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases