CMAUP Plant Collective Molecular Activities

Plant Name: Ficus carica

Taxonomic Information:

Plant ID: NPO22234
Plant Latin Name: Ficus carica
Taxonomy Genus: Ficus
Taxonomy Family: Moraceae

Plant External Links:

NCBI TaxonomyDB: 3494
Plant-of-the-World-Online: 852556-1

Used in Medicines:

Country/Region:

Turkey; Israel; Italy; Turkmenistan; India; Indonesia; Lebanon; China; Spain

Traditional Medicine System:

Indian Folk; TCM; Unani; Ayurveda; Siddha

Medicinal Functions:

Cancer; Demulcent; Digestive; Emollient; Galactogogue; Laxative; Pectoral; Stings; Stomachic; Tonic; Warts

Geographical Distribution:

Turkey; Afghanistan; Italy; Bangladesh; Lebanon; France; Somalia; Peru; Turkmenistan; Israel; Iran; Algeria; El Salvador; Cape Verde; China; Iraq; Spain; Eritrea; Libya; Oman; Indonesia; Saudi Arabia; Mauritius; Morocco; Switzerland; New Zealand; Yemen; Russia; Bulgaria; United States; Albania; Portugal; Chad; Mexico; Egypt; Tajikistan; South Africa; India; United Kingdom; Tunisia; Austria; Greece; Hungary; Niger; Cyprus

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Hydrolase	ACHE;
Protein Kinase	ATM;
Lyase	CA2; CA9;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Enzyme_unclassified	HPGD; ALOX15; ALDH1A1;
Transcription Factor	TP53; NFKB1;
Unclassified	LMNA; FABP3;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP3A4; CYP2A6; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	ATM	Serine-protein kinase ATM	Q13315	CHEMBL3797
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.744E-11	1.494E-07	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.157E-10	1.871E-06	CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	9.011E-10	2.803E-06	CYP2A6, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.498E-08	4.009E-05	ALOX15, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	2.661E-07	1.756E-04	FFAR4, NFKB1, PPARA, PPARD, PPARG
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.639E-07	1.756E-04	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	3.681E-07	2.290E-04	CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	4.566E-07	2.687E-04	CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, PPARD
MF	GO:0005488; binding	GO:0020037; heme binding	4.539E-07	2.687E-04	CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	1.133E-06	5.887E-04	CYP2A6, CYP2C19, CYP2C9
BP	GO:0051179; localization	GO:0015908; fatty acid transport	1.333E-06	6.451E-04	FABP3, PPARA, PPARD, PPARG
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	1.985E-06	8.823E-04	ACHE, ALDH1A1, CYP3A4, FFAR1, FFAR4, NFKB1, PPARD
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.209E-06	9.619E-04	CYP2A6, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	2.334E-06	9.966E-04	ALOX15, PPARA, PPARD, TP53
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	4.435E-06	1.725E-03	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	8.864E-06	3.101E-03	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.116E-05	3.739E-03	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	1.476E-05	4.592E-03	PPARA, PPARG
BP	GO:0050896; response to stimulus	GO:0043434; response to peptide hormone	2.023E-05	5.507E-03	FABP3, NFKB1, PPARA, PPARG, TSHR
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	2.213E-05	5.668E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	2.213E-05	5.668E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	2.213E-05	5.668E-03	ALOX15, HPGD
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	2.213E-05	5.668E-03	FABP3, PPARG
BP	GO:0008283; cell proliferation	GO:0048662; negative regulation of smooth muscle cell proliferation	2.810E-05	6.953E-03	PPARD, PPARG, TP53
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	3.002E-05	7.021E-03	ACHE, ALOX15, ATM, CA2, HPGD, LMNA, PPARA, PPARD, PPARG, SMN1, SMN2, TP53, TSHR
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	3.095E-05	7.021E-03	CYP2A6, CYP2D6
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	2.991E-05	7.021E-03	PPARA, PPARD, PPARG
MF	GO:0005488; binding	GO:0097371; MDM2/MDM4 family protein binding	3.095E-05	7.021E-03	PPARA, TP53
MF	GO:0005488; binding	GO:0043621; protein self-association	4.010E-05	8.910E-03	ACHE, PPARG, TP53
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	7.607E-05	1.492E-02	CA2, CA9, HPGD, TSHR
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	9.691E-05	1.716E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	1.144E-04	1.932E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	2.236E-04	3.246E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.704E-08	1.704E-06	CYP2C9, CYP2A6, CYP2D6, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.712E-08	1.856E-06	CYP2C9, ALOX15, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.028E-06	3.271E-05	CYP2C9, CYP2A6, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.642E-06	3.284E-05	CYP2C9, CYP2A6, CYP2D6, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.308E-06	3.271E-05	FABP3, PPARG, PPARA, PPARD
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	2.066E-06	3.444E-05	HPGD, ATM, PPARG, TP53, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	9.082E-06	1.135E-04	CYP2C9, CYP2D6, ALOX15, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.620E-06	3.743E-05	CYP2C9, CYP2A6, CYP3A4, CYP2C19
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.192E-05	2.435E-04	LMNA, ATM, TP53, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.481E-05	5.481E-04	CYP2C9, ALOX15, CYP2C19
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.894E-04	1.579E-03	PPARG, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.186E-03	7.908E-03	PPARG, TP53, NFKB1, PPARD
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	5.253E-04	3.924E-03	PPARA, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.683E-03	9.902E-03	PPARA, NFKB1, TSHR
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	5.493E-04	3.924E-03	PPARG, TP53
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.383E-03	8.644E-03	CYP2A6, CYP3A4
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.856E-04	1.579E-03	CA2, CA9

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases