CMAUP Plant Collective Molecular Activities

Plant Name: Rhodiola crenulata

Taxonomic Information:

Plant ID: NPO22230
Plant Latin Name: Rhodiola crenulata
Taxonomy Genus: Rhodiola
Taxonomy Family: Crassulaceae

Plant External Links:

NCBI TaxonomyDB: 242839
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; TERT; CBR1; HSD17B10; PGD; POLB;
Miscellaneous ion channel	BCL2;
Protein Kinase	FYN;
Lyase	CA2; CA14; CA7; CA6;
Lysine demethylase	KDM4E;
Transferase	FUT7;
DNA methyltransferase	DNMT1;
ATP-binding cassette	ABCB1;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
DNA methyltransferase	DNMT1	DNA (cytosine-5)-methyltransferase 1	P26358	CHEMBL1993
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Protein Kinase	FYN	Tyrosine-protein kinase FYN	P06241	CHEMBL1841
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	7.157E-10	1.559E-05	CA14, CA2, CA6, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.999E-08	3.536E-04	CA14, CA2, CA6, CA7
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	8.120E-08	3.536E-04	ABCB1, CA2, CA7
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.459E-06	5.950E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	3.993E-06	7.904E-03	BCL2, FYN, TERT
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.759E-06	8.635E-03	CA2, CA6, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.085E-09	6.509E-08	CA2, CA7, CA6, CA14

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Tumors	C00-D48	TERT;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	DNMT1;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT; DNMT1;
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
J00-J99: Diseases of the respiratory system	Asthma	J45	CBR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	BCL2;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	ABCB1;
C00-D49: Neoplasms	Soft tissue sarcoma	C00-D49	DNMT1;
C00-D49: Neoplasms	Multiple myeloma	C90	TERT; BCL2;
C00-D49: Neoplasms	Liver cancer	C22	TERT;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
C00-D49: Neoplasms	Breast cancer	C50	TERT; BCL2;
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT;
C00-D49: Neoplasms	Prostate cancer	C61	TERT; BCL2;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	DNMT1;
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
C00-D49: Neoplasms	Ovarian cancer	C56	TERT; ABCB1;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ABCB1;
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	DNMT1; ABCB1;
C00-D49: Neoplasms	Solid tumours	C00-D48	ABCB1;
C00-D49: Neoplasms	Melanoma	C43	TERT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Cancer	C00-C96	DNMT1; ABCB1; BCL2;
C00-D49: Neoplasms	Leukemia	C90-C95	BCL2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	DNMT1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases