Plant Name: Chimonanthus fragrans
Taxonomic Information:
Plant ID: NPO22216
Plant Latin Name: Chimonanthus fragrans
Taxonomy Genus: Chimonanthus
Taxonomy Family: Calycanthaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.688E-06 | 3.675E-02 | CA4, CA6 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.012E-05 | 1.102E-01 | CA4, CA6 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.519E-05 | 1.103E-01 | CA4, CA6 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 7.430E-05 | 2.696E-01 | CA4, CA6, PTPN1 |
| BP | GO:0050896; response to stimulus | GO:0060397; JAK-STAT cascade involved in growth hormone signaling pathway | 2.328E-03 | 1.000E+00 | PTPN1 |
| BP | GO:0051179; localization | GO:0006820; anion transport | 2.339E-03 | 1.000E+00 | CA4, CA6 |
| BP | Unclassified; | GO:0061098; positive regulation of protein tyrosine kinase activity | 6.664E-03 | 1.000E+00 | PTPN1 |
| CC | GO:0044464; cell part | GO:0005791; rough endoplasmic reticulum | 7.437E-03 | 1.000E+00 | CA4 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 2.861E-02 | 1.000E+00 | CA4 |
| MF | GO:0003824; catalytic activity | GO:0004721; phosphoprotein phosphatase activity | 2.770E-02 | 1.000E+00 | PTPN1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 2.039E-06 | 1.020E-05 | CA4, CA6 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 3.446E-03 | 8.616E-03 | CA4 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.106E-02 | 1.843E-02 | PTPN1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 1.626E-02 | 2.033E-02 | PTPN1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 2.071E-02 | 2.071E-02 | PTPN1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
