CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Transient receptor potential channel	TRPA1;
Protein Kinase	MAPK1;
Enzyme_unclassified	ALDH1A1;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 7 of 7 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0019233; sensory perception of pain	1.538E-04	7.174E-01	MAPK1, TRPA1
BP	GO:0009987; cellular process	GO:1900034; regulation of cellular response to heat	3.337E-04	7.174E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	2.461E-04	7.174E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0032421; stereocilium bundle	1.811E-03	7.886E-01	TRPA1
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	7.247E-04	7.514E-01	TSHR
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	7.247E-04	7.514E-01	CYP2A6
MF	GO:0005488; binding	GO:0005497; androgen binding	1.449E-03	7.771E-01	ALDH1A1
MF	GO:0005488; binding	GO:0019902; phosphatase binding	1.463E-03	7.771E-01	MAPK1, MAPT
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	2.534E-03	8.478E-01	ALDH1A1
MF	GO:0005488; binding	GO:0034452; dynactin binding	3.980E-03	9.420E-01	MAPT

Showing 1 to 10 of 10 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.161E-04	2.183E-02	CYP2A6, ALDH1A1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.749E-03	4.044E-02	CYP2A6
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.002E-03	4.044E-02	MAPK1, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	3.260E-03	5.487E-02	MAPK1, MAPT
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	3.006E-02	5.769E-02	MAPK1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	9.984E-04	4.044E-02	LMNA, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	2.459E-02	5.769E-02	TSHR
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.433E-03	4.044E-02	MAPK1, MAPT
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	2.528E-02	5.769E-02	MAPK1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	3.074E-02	5.769E-02	MAPK1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;

Showing 1 to 6 of 6 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Centranthus longiflorus ssp. longiflorus

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities