Plant Name: Centranthus longiflorus ssp. longiflorus
Taxonomic Information:
Plant ID: NPO22178.1
Plant Latin Name: Centranthus longiflorus ssp. longiflorus
Taxonomy Genus: Centranthus
Taxonomy Family: Caprifoliaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| TRPA1; | |
| MAPK1; | |
| ALDH1A1; | |
| MAPT; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2A6; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0019233; sensory perception of pain | 1.538E-04 | 7.174E-01 | MAPK1, TRPA1 |
| BP | GO:0009987; cellular process | GO:1900034; regulation of cellular response to heat | 3.337E-04 | 7.174E-01 | MAPK1, MAPT |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 2.461E-04 | 7.174E-01 | MAPK1, MAPT |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 7.247E-04 | 7.514E-01 | TSHR |
| MF | GO:0003824; catalytic activity | GO:0008389; coumarin 7-hydroxylase activity | 7.247E-04 | 7.514E-01 | CYP2A6 |
| MF | GO:0005488; binding | GO:0005497; androgen binding | 1.449E-03 | 7.771E-01 | ALDH1A1 |
| MF | GO:0005488; binding | GO:0019902; phosphatase binding | 1.463E-03 | 7.771E-01 | MAPK1, MAPT |
| CC | GO:0044464; cell part | GO:0032421; stereocilium bundle | 1.811E-03 | 7.886E-01 | TRPA1 |
| MF | GO:0003824; catalytic activity | GO:0001758; retinal dehydrogenase activity | 2.534E-03 | 8.478E-01 | ALDH1A1 |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 3.980E-03 | 9.420E-01 | MAPT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 2.161E-04 | 2.183E-02 | CYP2A6, ALDH1A1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 9.984E-04 | 4.044E-02 | LMNA, MAPK1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 1.433E-03 | 4.044E-02 | MAPK1, MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 2.002E-03 | 4.044E-02 | MAPK1, TSHR |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 3.260E-03 | 5.487E-02 | MAPK1, MAPT |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 1.749E-03 | 4.044E-02 | CYP2A6 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 2.528E-02 | 5.769E-02 | MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 2.459E-02 | 5.769E-02 | TSHR |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04012 | ErbB signaling pathway | 3.006E-02 | 5.769E-02 | MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 3.074E-02 | 5.769E-02 | MAPK1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | MAPK1; |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MAPK1; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1; |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
