Plant ID: NPO22125
Plant Latin Name: Helipterum propinquum
Taxonomy Genus: Helipterum
Taxonomy Family: Asteraceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
PPARD; PPARA; | |
TLR2; | |
MAPT; FABP3; FABP2; FABP4; LMNA; FABP5; |
Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 2.737E-10 | 1.986E-06 | FABP2, FABP3, FABP4, FABP5 |
BP | GO:0051179; localization | GO:0015908; fatty acid transport | 3.301E-06 | 4.492E-03 | FABP3, PPARA, PPARD |
BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 3.775E-06 | 4.835E-03 | LMNA, PPARA, PPARD, TLR2 |
MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 2.244E-04 | 1.241E-01 | PPARA, PPARD |
MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 3.257E-04 | 1.477E-01 | PPARA, PPARD |
CC | Unclassified; | GO:0106003; amyloid-beta complex | 5.115E-03 | 5.017E-01 | TLR2 |
CC | GO:0044464; cell part | GO:0030673; axolemma | 7.432E-03 | 5.928E-01 | MAPT |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.125E-13 | 3.823E-12 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
09150 Organismal Systems | 09154 Digestive system | hsa04975 | Fat digestion and absorption | 1.830E-02 | 8.790E-02 | FABP2 |
09160 Human Diseases | 09167 Infectious diseases | hsa05144 | Malaria | 2.184E-02 | 8.790E-02 | TLR2 |
09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 2.536E-02 | 8.790E-02 | PPARD |
09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 2.448E-02 | 8.790E-02 | TLR2 |
09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 2.492E-02 | 8.790E-02 | FABP4 |
09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 2.888E-02 | 8.790E-02 | TLR2 |
09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 3.238E-02 | 8.790E-02 | TLR2 |
09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 3.107E-02 | 8.790E-02 | PPARA |
09140 Cellular Processes | 09141 Transport and catabolism | hsa04145 | Phagosome | 6.722E-02 | 8.790E-02 | TLR2 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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