CMAUP Plant Collective Molecular Activities

Plant Name: Paulownia tomentosa

Taxonomic Information:

Plant ID: NPO22079
Plant Latin Name: Paulownia tomentosa
Taxonomy Genus: Paulownia
Taxonomy Family: Paulowniaceae

Plant External Links:

NCBI TaxonomyDB: 39353
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Astringent; Skin; Vermifuge; Warts

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; OPRD1;
Hydrolase	GAA; BCHE; ACHE;
Enzyme_unclassified	TDP1; HSD17B1; POLB;
Protein Kinase	MAPK1; KIT; PRKCA;
Lyase	CA12; CA7; CA4;
Oxidoreductase	PTGS2;
Transcription Factor	HIF1A;
Unclassified	NPC1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C19; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	BCHE	Butyrylcholinesterase	P06276	CHEMBL1914
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	KIT	Stem cell growth factor receptor	P10721	CHEMBL1936
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.779E-09	1.937E-05	CYP19A1, CYP1A1, CYP1B1, CYP2C19, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	6.926E-09	3.952E-05	CYP19A1, CYP1A1, CYP1B1, CYP2C19, CYP3A4, PTGS2
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.332E-08	4.144E-05	CYP19A1, CYP1A1, CYP1B1, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.760E-07	2.395E-04	CYP1A1, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	2.026E-07	2.595E-04	BCHE, CYP1A1, CYP1B1, CYP2C19, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.647E-07	6.597E-04	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.092E-06	8.872E-04	CYP19A1, CYP1A1, CYP1B1, CYP2C19, CYP3A4
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	1.356E-06	1.055E-03	ACHE, BCHE
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.934E-06	1.276E-03	CYP1A1, CYP1B1, CYP2C19
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	4.066E-06	2.459E-03	CYP1A1, CYP3A4
BP	GO:0032501; multicellular organismal process	GO:0010575; positive regulation of vascular endothelial growth factor production	4.234E-06	2.492E-03	CYP1B1, HIF1A, PTGS2
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	5.557E-06	2.931E-03	CYP19A1, CYP1A1, CYP1B1, CYP2C19, CYP3A4, GAA, HSD17B1, PTGS2
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.026E-05	4.469E-03	CA12, CA4, CA7
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	1.353E-05	5.667E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0032787; monocarboxylic acid metabolic process	1.589E-05	6.291E-03	CYP1A1, CYP1B1, CYP2C19, HIF1A, NPC1, PTGS2
BP	GO:0007610; behavior	GO:0007612; learning	1.876E-05	6.982E-03	BCHE, HIF1A, KIT, PTGS2
BP	GO:0032501; multicellular organismal process	GO:0043536; positive regulation of blood vessel endothelial cell migration	1.892E-05	6.982E-03	HIF1A, PRKCA, PTGS2
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.892E-05	6.982E-03	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	2.028E-05	7.124E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.028E-05	7.124E-03	CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	2.754E-05	9.363E-03	ACHE, BCHE, CYP1A1, CYP1B1, CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	2.838E-05	9.363E-03	BCHE, CYP3A4
BP	GO:0032502; developmental process	GO:0045766; positive regulation of angiogenesis	3.057E-05	9.937E-03	CYP1B1, HIF1A, PRKCA, PTGS2
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	6.854E-05	1.756E-02	CYP19A1, CYP1A1, CYP1B1, CYP2C19, CYP3A4, PTGS2, RAB9A
CC	GO:0044464; cell part	GO:0005764; lysosome	2.836E-04	4.980E-02	GAA, KIT, NPC1, RAB9A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.586E-09	3.517E-07	HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.559E-09	3.780E-07	HSD17B1, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.251E-08	1.474E-06	CYP1A1, CYP1B1, CYP3A4, CYP2C19, PTGS2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	7.601E-06	2.067E-04	MAPK1, PRKCA, CYP2C19, PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	4.356E-05	8.893E-04	MAPK1, PRKCA, HIF1A
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	7.529E-05	1.066E-03	KIT, MAPK1, PRKCA, PTGS2, HIF1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	4.578E-05	8.893E-04	MAPK1, PRKCA, PTGS2
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.939E-07	3.039E-05	CA12, CA4, CA7
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	6.066E-05	1.031E-03	KIT, MAPK1, HIF1A
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.840E-05	1.066E-03	CYP1A1, CYP1B1, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04916	Melanogenesis	1.997E-04	2.117E-03	KIT, MAPK1, PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	2.057E-04	2.117E-03	MAPK1, PRKCA, PTGS2
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	2.717E-04	2.464E-03	ACHE, MAPK1, PRKCA
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	2.057E-04	2.117E-03	MAPK1, PRKCA, HIF1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	2.180E-04	2.117E-03	MAPK1, PRKCA, HIF1A
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.502E-04	2.507E-03	GAA, HSD17B1, CYP1A1, PTGS2, CYP2C19, CYP3A4, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	3.377E-04	2.507E-03	CYP1B1, MAPK1, PRKCA, PTGS2
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	3.253E-04	2.507E-03	MAPK1, PRKCA, HIF1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	3.417E-04	2.507E-03	OPRD1, MAPK1, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04072	Phospholipase D signaling pathway	5.825E-04	3.772E-03	KIT, MAPK1, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04921	Oxytocin signaling pathway	7.628E-04	4.715E-03	MAPK1, PRKCA, PTGS2
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.571E-03	8.545E-03	MAPK1, PRKCA, HIF1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.754E-03	9.111E-03	KIT, MAPK1, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	2.161E-03	9.479E-03	KIT, MAPK1, PRKCA
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	1.876E-03	9.111E-03	MAPK1, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.876E-03	9.111E-03	PTGS2, TSHR
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.943E-03	9.111E-03	KIT, MAPK1
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	2.518E-03	9.803E-03	MAPK1, PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	2.150E-03	9.479E-03	MAPK1, PRKCA
09150 Organismal Systems	09155 Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	9.135E-04	5.401E-03	MAPK1, PRKCA
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	9.609E-04	5.445E-03	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.294E-03	9.749E-03	CYP2C19, PTGS2
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	2.595E-03	9.803E-03	MAPK1, PRKCA
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	2.595E-03	9.803E-03	MAPK1, HIF1A
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.518E-03	9.803E-03	CYP1A1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.040E-04	3.427E-03	CYP3A4, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases