CMAUP Plant Collective Molecular Activities

Plant Name: Mannia fragrans

Plant ID: NPO22064
Plant Latin Name: Mannia fragrans
Taxonomy Genus: Mannia
Taxonomy Family: Aytoniaceae

NCBI TaxonomyDB: 179045
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Nuclear hormone receptor subfamily 1 group C	PPARD; PPARA;
Toll-like and Il-1 receptors	TLR2;
Unclassified	MAPT; FABP3; FABP2; FABP4; LMNA; FABP5;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.737E-10	1.986E-06	FABP2, FABP3, FABP4, FABP5
BP	GO:0051179; localization	GO:0015908; fatty acid transport	3.301E-06	4.492E-03	FABP3, PPARA, PPARD
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	3.775E-06	4.835E-03	LMNA, PPARA, PPARD, TLR2
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	2.244E-04	1.241E-01	PPARA, PPARD
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	3.257E-04	1.477E-01	PPARA, PPARD
CC	Unclassified;	GO:0106003; amyloid-beta complex	5.115E-03	5.017E-01	TLR2
CC	GO:0044464; cell part	GO:0030673; axolemma	7.432E-03	5.928E-01	MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.125E-13	3.823E-12	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09154 Digestive system	hsa04975	Fat digestion and absorption	1.830E-02	8.790E-02	FABP2
09160 Human Diseases	09167 Infectious diseases	hsa05144	Malaria	2.184E-02	8.790E-02	TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	3.238E-02	8.790E-02	TLR2
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	3.107E-02	8.790E-02	PPARA
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	6.128E-02	8.790E-02	LMNA
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	5.829E-02	8.790E-02	PPARA
09130 Environmental Information Processing	09132 Signal transduction	hsa04310	Wnt signaling pathway	6.213E-02	8.790E-02	PPARD
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	6.595E-02	8.790E-02	PPARA
09140 Cellular Processes	09141 Transport and catabolism	hsa04145	Phagosome	6.722E-02	8.790E-02	TLR2

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases