Plant Name: Hippomane mancinella
Taxonomic Information:
Plant ID: NPO22060
Plant Latin Name: Hippomane mancinella
Taxonomy Genus: Hippomane
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
316844
Plant-of-the-World-Online:
349995-1
Used in Medicines:
Unknown.
Geographical Distribution:
Jamaica; Netherlands; Honduras; Cuba; El Salvador; Venezuela; Mexico; Costa Rica; Bahamas; Trinidad and Tobago; Guatemala; Colombia; Guyana; Dominican Republic; Belize; Nicaragua; Haiti; Ecuador; United States
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| SLCO1B3; SLCO1B1; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0043252; sodium-independent organic anion transport | 6.074E-06 | 3.805E-02 | SLCO1B1, SLCO1B3 |
| BP | GO:0051179; localization | GO:0015721; bile acid and bile salt transport | 6.989E-06 | 3.805E-02 | SLCO1B1, SLCO1B3 |
| MF | GO:0005215; transporter activity | GO:0015125; bile acid transmembrane transporter activity | 2.459E-06 | 3.805E-02 | SLCO1B1, SLCO1B3 |
| MF | GO:0005215; transporter activity | GO:0015347; sodium-independent organic anion transmembrane transporter activity | 4.435E-06 | 3.805E-02 | SLCO1B1, SLCO1B3 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 2.749E-04 | 4.989E-01 | SLCO1B1, SLCO1B3 |
| BP | GO:0051179; localization | GO:0006811; ion transport | 1.309E-02 | 1.000E+00 | SLCO1B1, SLCO1B3 |
| BP | GO:0065007; biological regulation | GO:0009914; hormone transport | 1.314E-02 | 1.000E+00 | SLCO1B1 |
| CC | GO:0044425; membrane part | GO:0005887; integral component of plasma membrane | 1.518E-02 | 1.000E+00 | SLCO1B1, SLCO1B3 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 3.719E-05 | 3.719E-05 | SLCO1B1, SLCO1B3 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
