CMAUP Plant Collective Molecular Activities

Plant Name: Gelsemium elegans

Taxonomic Information:

Plant ID: NPO21995
Plant Latin Name: Gelsemium elegans
Taxonomy Genus: Gelsemium
Taxonomy Family: Gelsemiaceae

Plant External Links:

NCBI TaxonomyDB: 427660
Plant-of-the-World-Online: 546348-1

Used in Medicines:

Country/Region:

Thailand

Traditional Medicine System:

Geographical Distribution:

Myanmar; Indonesia; India; Vietnam; China; Laos; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; HPGD;
Bromodomain	CREBBP;
Unclassified	MAPT; HTT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Bromodomain	CREBBP	CREB-binding protein	Q92793	CHEMBL5747
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	4.502E-07	9.803E-03	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.250E-06	2.286E-02	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	9.886E-06	4.305E-02	CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0034452; dynactin binding	8.240E-06	4.305E-02	HTT, MAPT
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.781E-05	1.372E-01	CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0010821; regulation of mitochondrion organization	8.476E-05	2.051E-01	HTT, LMNA, MAPT
BP	GO:0065007; biological regulation	GO:0031648; protein destabilization	1.282E-04	2.467E-01	CREBBP, HTT
BP	GO:0009987; cellular process	GO:0042981; regulation of apoptotic process	1.325E-04	2.467E-01	CREBBP, HPGD, HTT, LMNA, MAPT
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.473E-04	2.467E-01	CYP2D6, CYP3A4
CC	GO:0043226; organelle	GO:0016604; nuclear body	2.450E-03	5.751E-01	CREBBP, LMNA, MAPT
CC	GO:0044464; cell part	GO:0030424; axon	4.683E-03	7.531E-01	HTT, MAPT
CC	GO:0044464; cell part	GO:0030673; axolemma	6.609E-03	8.951E-01	MAPT
CC	GO:0044464; cell part	GO:0030425; dendrite	7.791E-03	9.649E-01	HTT, MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.241E-04	7.618E-03	CYP2D6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.627E-04	7.618E-03	CYP2D6, CYP3A4
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05016	Huntington's disease	2.497E-03	3.495E-02	CREBBP, HTT
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.154E-02	8.094E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.826E-02	8.094E-02	CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04330	Notch signaling pathway	1.904E-02	8.094E-02	CREBBP
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	2.610E-02	8.094E-02	CREBBP
09150 Organismal Systems	09152 Endocrine system	hsa04916	Melanogenesis	3.931E-02	8.094E-02	CREBBP
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	3.544E-02	8.094E-02	LMNA
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	4.047E-02	8.094E-02	CREBBP

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Chronic myeloid leukemia	NA	CREBBP;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	CREBBP;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases