CMAUP Plant Collective Molecular Activities

Plant Name: Clausena harmandiana

Taxonomic Information:

Plant ID: NPO21978
Plant Latin Name: Clausena harmandiana
Taxonomy Genus: Clausena
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 159036
Plant-of-the-World-Online: 772134-1

Used in Medicines:

Country/Region:

Laos

Traditional Medicine System:

Geographical Distribution:

Thailand; Myanmar; Cambodia; Laos

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA1; CA7; CA12; CA9; CA13;
Unclassified	XBP1; RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Unclassified	XBP1	X-box-binding protein 1	P17861	CHEMBL1741176
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	7.499E-15	1.633E-10	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	9.388E-13	1.022E-08	CA1, CA12, CA13, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.702E-12	1.961E-08	CA1, CA12, CA13, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.573E-06	1.101E-02	CA1, CA12, CA13, CA7, CA9
CC	GO:0044464; cell part	GO:0005764; lysosome	5.306E-03	1.000E+00	NPC1, RAB9A
CC	GO:0043226; organelle	GO:0042470; melanosome	4.108E-02	1.000E+00	RAB9A
MF	GO:0005488; binding	GO:0005496; steroid binding	3.507E-02	1.000E+00	NPC1
MF	GO:0005488; binding	GO:0001158; enhancer sequence-specific DNA binding	3.748E-02	1.000E+00	XBP1
MF	GO:0005488; binding	GO:0001085; RNA polymerase II transcription factor binding	4.705E-02	1.000E+00	XBP1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.298E-14	7.789E-14	CA12, CA1, CA7, CA9, CA13
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	5.884E-02	7.877E-02	XBP1
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	4.816E-02	7.877E-02	NPC1
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	5.313E-02	7.877E-02	RAB9A
09120 Genetic Information Processing	09123 Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6.565E-02	7.877E-02	XBP1
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	9.868E-02	9.868E-02	XBP1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases