CMAUP Plant Collective Molecular Activities

Plant Name: Coleus carnosus

Taxonomic Information:

Plant ID: NPO21938
Plant Latin Name: Coleus carnosus
Taxonomy Genus: Coleus
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Indonesia

Traditional Medicine System:

Geographical Distribution:

Indonesia

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Nuclear hormone receptor subfamily 0 group B	NR0B1;
Nuclear hormone receptor subfamily 3 group C	NR3C1;
Transcription Factor	HIF1A;
SLC superfamily of solute carriers	SLC6A2; SLC6A3; SLCO1B3; SLCO1B1;
Unclassified	PAX8; RAB9A; NPC1; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 0 group B	NR0B1	Nuclear receptor subfamily 0 group B member 1	P51843	CHEMBL1795094
Nuclear hormone receptor subfamily 3 group C	NR3C1	Glucocorticoid receptor	P04150	CHEMBL2034
SLC superfamily of solute carriers	SLC6A2	Norepinephrine transporter	P23975	CHEMBL222
SLC superfamily of solute carriers	SLC6A3	Dopamine transporter	Q01959	CHEMBL238
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.312E-09	2.028E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.021E-07	5.559E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.278E-06	5.567E-03	CYP2C19, CYP2C9, CYP3A4, NPC1, NR0B1
MF	GO:0005215; transporter activity	GO:0005330; dopamine:sodium symporter activity	1.929E-06	6.168E-03	SLC6A2, SLC6A3
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.747E-06	7.477E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.856E-06	8.396E-03	CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	6.478E-06	1.282E-02	CYP2C19, CYP2C9, CYP3A4
BP	GO:0023052; signaling	GO:0051583; dopamine uptake involved in synaptic transmission	9.631E-06	1.311E-02	SLC6A2, SLC6A3
BP	GO:0009987; cellular process	GO:2001054; negative regulation of mesenchymal cell apoptotic process	2.884E-05	2.990E-02	HIF1A, PAX8
MF	GO:0005215; transporter activity	GO:0015291; secondary active transmembrane transporter activity	3.886E-05	3.539E-02	SLC6A2, SLC6A3, SLCO1B1, SLCO1B3
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	4.225E-05	3.539E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	4.991E-05	3.748E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.516E-06	5.304E-05	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.131E-05	2.710E-04	CYP2C9, CYP3A4, CYP2C19
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.323E-05	2.710E-04	SLCO1B1, SLCO1B3, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.579E-05	3.132E-04	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.103E-03	7.070E-03	CYP2C9, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.212E-03	7.070E-03	CYP2C9, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.526E-03	7.628E-03	CYP2C9, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.543E-03	1.550E-02	CYP2C9, CYP2C19
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	8.152E-03	3.170E-02	SMN2, SMN1
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	2.296E-02	8.035E-02	PAX8

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Cushing's disease	E24.0	NR3C1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	NR3C1;
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	NR3C1;
NA: NA	Corticosteroid-responsive inflammation	NA	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Duchenne muscular dystrophy	G71.0	NR3C1;
H60-H95: Diseases of the ear and mastoid process	Otitis externa	H60	NR3C1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Eczema	L20-L30	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	NR3C1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	NR3C1;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	NR3C1;
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Ataxia telangiectasia	G11.3	NR3C1;
J00-J99: Diseases of the respiratory system	Asthma	J45	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Xerophthalmia	E50.6-E50.7	NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	NR3C1;
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	NR3C1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Skin allergies	T78.4	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Spinal cord injury	S14, S24, S34	NR3C1;
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NR3C1;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	NR3C1;
NA: NA	Non-infectious rhinitis	NA	NR3C1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases