CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NMUR2;
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A;
Hydrolase	GAA; ACHE;
Protein Kinase	MAPK1;
Lyase	CA2; CA1; CA12; CA9; CA13; CA14; CA7; CA4; CA6;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	HPGD; GFER; HSD17B10; ALOX15; ALDH1A1; POLB;
Cysteine protease	CASP1; CASP7;
Transcription Factor	HIF1A;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Oxidoreductase	XDH;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.989E-06	7.247E-03	CA2, CA7
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	7.600E-06	7.522E-03	CASP1, CASP7, MAPT, XDH
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	1.018E-05	9.639E-03	ACHE, ADRA2A, ADRA2C, ALDH1A1, HIF1A, NR1H4, SLCO1B1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.519E-18	8.553E-14	CA1, CA12, CA13, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.587E-16	1.562E-12	CA1, CA12, CA13, CA2, CA4, CA6, CA7, CA9
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.157E-08	2.100E-05	ADRA2A, CA2, CA4, CA9, HPGD, SLCO1B1, SLCO1B3
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.514E-04	4.810E-02	HIF1A, MAPK1, MAPT
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.556E-06	3.092E-03	CA1, CA12, CA13, CA2, CA4, CA6, CA7, CA9, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	6.989E-06	7.247E-03	ADRA2A, ADRA2C
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.914E-23	1.506E-18	CA1, CA12, CA13, CA14, CA2, CA4, CA6, CA7, CA9

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.451E-22	2.892E-20	CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14, CA13
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.169E-05	8.531E-04	CYP1A2, XDH
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.611E-04	1.452E-02	CYP1A2, ALOX15
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	1.967E-03	2.901E-02	MAPK1, ADRA2C, ADRA2A
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.726E-06	2.198E-04	SLCO1B1, CA2, SLCO1B3, NR1H4
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.396E-04	1.061E-02	CA2, CA4
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.110E-04	3.275E-03	CASP7, MAPK1, MAPT, HSD17B10
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	1.912E-04	4.512E-03	CASP7, CASP1, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	3.074E-03	3.815E-02	CASP7, CASP1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	4.527E-03	3.815E-02	MAPK1, HIF1A

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Berberis crataegina

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities