CMAUP Plant Collective Molecular Activities

Plant Name: Nuxia sphaerocephala

Taxonomic Information:

Plant ID: NPO21782
Plant Latin Name: Nuxia sphaerocephala
Taxonomy Genus: Nuxia
Taxonomy Family: Stilbaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: 546852-1

Used in Medicines:

Country/Region:

Madagascar

Traditional Medicine System:

Geographical Distribution:

Madagascar

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD1;
Hydrolase	BCHE; ACHE;
Transcription Factor	HIF1A;
Unclassified	MAPT; NPC1; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2D6; CYP1A2; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Hydrolase	BCHE	Butyrylcholinesterase	P06276	CHEMBL1914
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	8.517E-11	3.345E-07	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	8.517E-11	3.345E-07	CYP1A2, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.069E-10	3.345E-07	BCHE, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.075E-10	3.345E-07	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.212E-09	2.639E-06	CYP1A2, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	7.907E-09	1.435E-05	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	2.254E-08	3.068E-05	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.626E-08	4.156E-05	CYP1A2, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0005506; iron ion binding	6.904E-08	6.833E-05	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.000E-07	3.629E-04	CYP1A2, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	4.878E-07	4.249E-04	ACHE, BCHE
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	5.322E-07	4.457E-04	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.463E-06	9.653E-04	CYP2D6, CYP3A4
BP	GO:0023052; signaling	GO:0050805; negative regulation of synaptic transmission	1.230E-05	7.240E-03	ACHE, BCHE, DRD1
BP	GO:0009987; cellular process	GO:0019896; axonal transport of mitochondrion	1.751E-05	9.300E-03	HIF1A, MAPT
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	5.361E-16	1.167E-11	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	2.496E-05	1.235E-02	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, DRD1
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	3.206E-05	1.471E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	3.788E-05	1.617E-02	SMN1, SMN2
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	6.681E-05	2.552E-02	ACHE, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, DRD1, HIF1A, LMNA, MAPT, NPC1, SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	7.414E-05	2.691E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8.241E-10	3.379E-08	CYP2C9, CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.532E-09	7.240E-08	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.590E-07	2.173E-06	CYP2C9, CYP2D6, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.546E-07	2.610E-06	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.163E-05	9.533E-05	CYP2C9, CYP1A2, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	5.949E-05	4.065E-04	CYP2C9, CYP2D6, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	8.400E-04	4.305E-03	CYP2C9, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7.355E-04	4.305E-03	CYP1A2, CYP3A4
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	6.252E-03	2.563E-02	SMN2, SMN1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.495E-03	1.592E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; DRD1;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; DRD1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE; DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases