Plant ID: NPO21780
Plant Latin Name: Strychnos gossweileri
Taxonomy Genus: Strychnos
Taxonomy Family: Loganiaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Cytochrome P450 Enzymes: | CYP1A2; |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0050896; response to stimulus | GO:0046686; response to cadmium ion | 2.472E-05 | 5.383E-01 | CYP1A2, NPC1 |
BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 4.845E-04 | 9.220E-01 | CYP1A2, NPC1 |
BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 6.212E-04 | 9.220E-01 | CYP1A2 |
MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 6.212E-04 | 9.220E-01 | CYP1A2 |
CC | GO:0044464; cell part | GO:0030673; axolemma | 2.483E-03 | 1.000E+00 | MAPT |
CC | GO:0044464; cell part | GO:0036464; cytoplasmic ribonucleoprotein granule | 2.846E-02 | 1.000E+00 | MAPT |
MF | GO:0005488; binding | GO:0020037; heme binding | 1.975E-02 | 1.000E+00 | CYP1A2 |
MF | GO:0005488; binding | GO:0005506; iron ion binding | 2.465E-02 | 1.000E+00 | CYP1A2 |
MF | GO:0005488; binding | GO:0019902; phosphatase binding | 2.526E-02 | 1.000E+00 | MAPT |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 7.498E-04 | 8.998E-03 | CYP1A2 |
09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 5.988E-03 | 1.838E-02 | CYP1A2 |
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 4.344E-03 | 1.838E-02 | CYP1A2 |
09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 8.675E-03 | 1.838E-02 | CYP1A2 |
09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 9.719E-03 | 1.838E-02 | CYP1A2 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.031E-02 | 1.838E-02 | CYP1A2 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.091E-02 | 1.838E-02 | CYP1A2 |
09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.225E-02 | 1.838E-02 | CYP1A2 |
09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 1.834E-02 | 2.445E-02 | NPC1 |
09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 2.499E-02 | 2.999E-02 | MAPT |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT; |
G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; |
G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT; |