CMAUP Plant Collective Molecular Activities

Plant Name: Aconitum variegatum

Taxonomic Information:

Plant ID: NPO21600
Plant Latin Name: Aconitum variegatum
Taxonomy Genus: Aconitum
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: 112594
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1; ADRA2C; ADRA2A;
Peptide receptor (family A GPCR)	NMUR2;
Hydrolase	GAA; ACHE;
Enzyme_unclassified	TDP1; ADK; POLB;
Protein Kinase	MAPK1;
Transcription Factor	STAT6;
ATP-binding cassette	ABCB1; ABCG2;
SLC superfamily of solute carriers	SLC28A2; SLC28A1; SLC28A3;
Unclassified	RAB9A; NPC1; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
SLC superfamily of solute carriers	SLC28A2	Sodium/nucleoside cotransporter 2	O43868	CHEMBL5780
SLC superfamily of solute carriers	SLC28A1	Sodium/nucleoside cotransporter 1	O00337	CHEMBL5551
SLC superfamily of solute carriers	SLC28A3	Solute carrier family 28 member 3	Q9HAS3	CHEMBL5707
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Transcription Factor	STAT6	Signal transducer and activator of transcription 6	P42226	CHEMBL5401
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	4.318E-08	2.740E-04	CYP2C19, CYP2C9, CYP3A4
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	7.550E-08	2.740E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	1.809E-07	4.923E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	4.725E-07	1.029E-03	CYP2C19, CYP2C9, CYP3A4
CC	GO:0044464; cell part	GO:0030673; axolemma	1.198E-06	2.175E-03	ADORA1, ADORA2A, MAPT
BP	GO:0051179; localization	GO:0015860; purine nucleoside transmembrane transport	1.742E-06	2.232E-03	SLC28A2, SLC28A3
MF	GO:0005215; transporter activity	GO:0015389; pyrimidine- and adenine-specific:sodium symporter activity	1.742E-06	2.232E-03	SLC28A1, SLC28A3
MF	GO:0005215; transporter activity	GO:0015211; purine nucleoside transmembrane transporter activity	1.742E-06	2.232E-03	SLC28A2, SLC28A3
MF	GO:0005488; binding	GO:0042802; identical protein binding	3.504E-06	3.633E-03	ABCG2, ACHE, ADORA2A, ADRA2A, ADRA2C, MAPK1, MAPT, RAB9A, SMN1, SMN2, STAT6
BP	GO:0051179; localization	GO:1904823; purine nucleobase transmembrane transport	5.222E-06	3.668E-03	SLC28A1, SLC28A3
BP	GO:0051179; localization	GO:0015855; pyrimidine nucleobase transport	5.222E-06	3.668E-03	SLC28A1, SLC28A3
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	5.222E-06	3.668E-03	ADRA2A, ADRA2C
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	5.222E-06	3.668E-03	ADORA1, ADORA2A
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	1.044E-05	5.557E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	1.044E-05	5.557E-03	ADRA2A, ADRA2C
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.044E-05	5.557E-03	CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0032795; heterotrimeric G-protein binding	1.044E-05	5.557E-03	ADORA1, ADRA2A
BP	GO:0032501; multicellular organismal process	GO:0051930; regulation of sensory perception of pain	1.260E-05	5.838E-03	ADORA1, ADRA2C, NMUR2
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.260E-05	5.838E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0097159; organic cyclic compound binding	1.824E-05	7.496E-03	ABCB1, ABCG2, ADK, ADORA1, ADRA2A, ADRA2C, CYP2C19, CYP2C9, CYP3A4, MAPK1, MAPT, NMUR2, NPC1, POLB, RAB9A, SMN1, SMN2, STAT6, TDP1
BP	GO:0032501; multicellular organismal process	GO:0097746; regulation of blood vessel diameter	2.168E-05	8.430E-03	ADORA1, ADORA2A, ADRA2A, ADRA2C
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	5.702E-05	1.561E-02	ADORA1, ADORA2A, ADORA3, ADRA2A, ADRA2C, NPC1, SLC28A1, SLC28A2, SLC28A3
CC	GO:0044456; synapse part	GO:0099055; integral component of postsynaptic membrane	6.236E-05	1.561E-02	ADORA1, ADORA2A
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	1.140E-04	2.459E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.220E-06	1.244E-04	ADORA2A, ADORA3, ADORA1, NMUR2, ADRA2C, ADRA2A
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	2.182E-06	1.244E-04	ADORA3, ADORA1, MAPK1, ADRA2C, ADRA2A
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	6.968E-06	2.648E-04	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9.653E-05	2.397E-03	CYP2C9, CYP3A4, CYP2C19
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.051E-04	2.397E-03	ABCB1, CYP3A4, ABCG2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.613E-04	3.066E-03	CYP2C9, CYP3A4, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.046E-04	6.590E-03	CYP2C9, MAPK1, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	4.952E-04	7.056E-03	ADORA3, ADORA1, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.131E-03	2.429E-02	ADORA2A, ADORA1, MAPK1
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	1.487E-03	1.883E-02	ABCB1, ABCG2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; ADORA3;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; ADORA1; ADORA2A; ADORA3;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; ADORA1; ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE; ADORA2A; ADK;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE; ADK;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; ADORA1;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases