CMAUP Plant Collective Molecular Activities

Plant Name: Psorothamnus polydenius

Plant ID: NPO21591
Plant Latin Name: Psorothamnus polydenius
Taxonomy Genus: Psorothamnus
Taxonomy Family: Fabaceae

NCBI TaxonomyDB: 248535
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA7; CA4; CA12;
Metallo protease	MMP2; MMP12;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	7.567E-09	1.648E-04	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.184E-07	8.597E-04	CA12, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.195E-07	1.195E-03	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.559E-07	2.743E-03	CA12, CA4, CA7, MMP12, MMP2
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	1.658E-04	2.777E-01	MMP12, MMP2
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	2.451E-04	3.301E-01	MMP12, MMP2
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	2.905E-04	3.514E-01	MMP12, MMP2
MF	GO:0003824; catalytic activity	GO:0004222; metalloendopeptidase activity	5.189E-04	5.381E-01	MMP12, MMP2
CC	GO:0044421; extracellular region part	GO:0031012; extracellular matrix	9.874E-03	1.000E+00	MMP12, MMP2
CC	GO:0044464; cell part	GO:0005791; rough endoplasmic reticulum	1.482E-02	1.000E+00	CA4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.019E-08	1.528E-07	CA12, CA4, CA7
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.194E-02	4.081E-02	CYP1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6.881E-03	4.081E-02	CA4
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.491E-02	4.081E-02	CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.728E-02	4.081E-02	CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.170E-02	4.081E-02	CYP1B1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.992E-02	4.081E-02	MMP2
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	2.699E-02	4.081E-02	MMP2
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	2.934E-02	4.081E-02	MMP2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.435E-02	4.081E-02	CYP1B1

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases