CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Enzyme_unclassified	FAAH; TDP1; TERT; HPGD; ALOX15; ALDH1A1;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Nuclear hormone receptor subfamily 1 group I	NR1I2;
Oxidoreductase	PTGS1; PTGS2;
Toll-like and Il-1 receptors	TLR2;
ATP-binding cassette	ABCB1;
Unclassified	LMNA; FABP3; FABP5; FABP2; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
Enzyme_unclassified	FAAH	Anandamide amidohydrolase	O00519	CHEMBL2243
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235

Showing 1 to 10 of 22 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.571E-08	2.528E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	2.675E-08	3.641E-05	FABP3, FFAR1, PPARG, PTGS2, TLR2
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	7.112E-07	3.872E-04	ALOX15, HPGD, PTGS2
BP	GO:0051179; localization	GO:0015908; fatty acid transport	9.225E-07	4.783E-04	FABP3, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	5.383E-06	1.922E-03	LMNA, PPARD, PTGS2, TERT
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	8.028E-06	2.649E-03	FFAR4, PPARA, PPARD, PPARG
BP	GO:0008283; cell proliferation	GO:0008285; negative regulation of cell proliferation	8.761E-06	2.847E-03	FABP3, LMNA, PPARD, PPARG, PTGS2, TERT, TLR2
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	1.236E-05	3.686E-03	PPARA, PPARG
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	1.304E-05	3.838E-03	NR1I2, PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	1.699E-05	4.742E-03	FABP3, PPARA, PPARG, TLR2

Showing 1 to 10 of 25 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	4.189E-05	8.378E-04	ALOX15, PTGS2, PTGS1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.997E-02	1.331E-01	PPARA, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.963E-13	4.178E-11	FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3.883E-07	1.165E-05	FABP4, PTGS2, TSHR, PTGS1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.436E-04	3.654E-03	ALOX15, PTGS2, PTGS1
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	5.461E-03	5.461E-02	FAAH, PTGS2
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	2.895E-03	3.474E-02	PTGS2, TLR2
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	9.033E-03	7.742E-02	PPARG, PTGS2, PPARD
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.653E-02	1.240E-01	HPGD, PPARG
09160 Human Diseases	09162 Immune diseases	hsa05323	Rheumatoid arthritis	9.451E-02	1.673E-01	TLR2

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	PTGS2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS2;
C00-D49: Neoplasms	Pancreatic cancer	C25	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTGS2; FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PTGS2;

Showing 1 to 10 of 27 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Tephroseris integrifolia

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities