Plant Name: Centaurea spinosa
Taxonomic Information:
Plant ID: NPO21525
Plant Latin Name: Centaurea spinosa
Taxonomy Genus: Centaurea
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
363453
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| UBE2N; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP19A1; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Enzyme_unclassified | UBE2N | Ubiquitin-conjugating enzyme E2 N | P61088 | CHEMBL6089 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0061370; testosterone biosynthetic process | 5.177E-04 | 1.000E+00 | CYP19A1 |
| BP | GO:0032501; multicellular organismal process | GO:0060736; prostate gland growth | 1.139E-03 | 1.000E+00 | CYP19A1 |
| BP | GO:0008152; metabolic process | GO:0006703; estrogen biosynthetic process | 1.346E-03 | 1.000E+00 | CYP19A1 |
| BP | GO:0032502; developmental process | GO:0060065; uterus development | 1.449E-03 | 1.000E+00 | CYP19A1 |
| BP | GO:0032501; multicellular organismal process | GO:0030540; female genitalia development | 1.656E-03 | 1.000E+00 | CYP19A1 |
| BP | GO:0032501; multicellular organismal process | GO:0008585; female gonad development | 1.966E-03 | 1.000E+00 | CYP19A1 |
| BP | GO:0032502; developmental process | GO:0030879; mammary gland development | 2.277E-03 | 1.000E+00 | CYP19A1 |
| BP | GO:0008152; metabolic process | GO:0031058; positive regulation of histone modification | 8.473E-03 | 1.000E+00 | UBE2N |
| BP | GO:0002376; immune system process | GO:0002223; stimulatory C-type lectin receptor signaling pathway | 1.270E-02 | 1.000E+00 | UBE2N |
| BP | GO:0008152; metabolic process | GO:0016125; sterol metabolic process | 1.321E-02 | 1.000E+00 | CYP19A1 |
| BP | GO:0065007; biological regulation | GO:0051092; positive regulation of NF-kappaB transcription factor activity | 1.444E-02 | 1.000E+00 | UBE2N |
| BP | GO:0065007; biological regulation | GO:0000187; activation of MAPK activity | 1.475E-02 | 1.000E+00 | UBE2N |
| BP | GO:0009987; cellular process | GO:0050852; T cell receptor signaling pathway | 1.496E-02 | 1.000E+00 | UBE2N |
| BP | GO:0008152; metabolic process | GO:0022900; electron transport chain | 1.670E-02 | 1.000E+00 | CYP19A1 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 2.380E-03 | 1.000E+00 | CYP19A1 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 3.517E-03 | 1.000E+00 | CYP19A1 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 4.654E-03 | 1.000E+00 | CYP19A1 |
| MF | GO:0003824; catalytic activity | GO:0009055; electron transfer activity | 1.115E-02 | 1.000E+00 | CYP19A1 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 1.321E-02 | 1.000E+00 | CYP19A1 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 1.650E-02 | 1.000E+00 | CYP19A1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 4.994E-03 | 1.158E-02 | CYP19A1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 5.792E-03 | 1.158E-02 | CYP19A1 |
| 09120 Genetic Information Processing | 09123 Folding, sorting and degradation | hsa04120 | Ubiquitin mediated proteolysis | 1.365E-02 | 1.820E-02 | UBE2N |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.201E-01 | 1.201E-01 | CYP19A1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
