CMAUP Plant Collective Molecular Activities

Plant Name: Pterolobium hexapetalum

Taxonomic Information:

Plant ID: NPO21472
Plant Latin Name: Pterolobium hexapetalum
Taxonomy Genus: Pterolobium
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 1905003
Plant-of-the-World-Online: 516625-1

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Indian Folk

Geographical Distribution:

India; Bangladesh; Myanmar

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	BLM; RECQL; TDP1; GLO1; ALOX12; HSD17B1; CBR1; AKR1B1; HSD17B2; HSD17B10; NOX4; APEX1; POLB;
Hydrolase	ACHE;
Isomerase	TOP2A;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB; CSNK2A1;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Oxidoreductase	TYR; XDH;
Metallo protease	MMP12;
Transcription Factor	AHR; HIF1A;
Unclassified	LMNA; THPO;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C19; CYP2C9; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	GLO1	Glyoxalase I	Q04760	CHEMBL2424
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Isomerase	TOP2A	DNA topoisomerase II alpha	P11388	CHEMBL1806
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	8.205E-12	4.467E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, NOX4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.212E-11	5.277E-08	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	9.605E-10	1.494E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.558E-09	2.873E-06	ALOX12, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, XDH
MF	GO:0005488; binding	GO:0020037; heme binding	1.487E-08	1.349E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, NOX4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.138E-08	2.356E-05	CA12, CA2, CA4, CA7
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.009E-07	9.299E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.195E-07	9.559E-05	CYP1A2, CYP2C19, CYP2C9
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	2.625E-07	1.079E-04	AKR1B1, APEX1, AXL, CDK1, CYP1B1
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	8.037E-07	2.612E-04	AHR, CSNK2A1, HIF1A, KDR
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.033E-06	3.168E-04	CYP19A1, CYP1A1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.308E-06	3.747E-04	CA12, CA2, CA4, CA7
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.392E-06	6.351E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.974E-06	7.803E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	3.104E-06	7.995E-04	CYP19A1, HSD17B1, HSD17B2
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	3.427E-06	8.488E-04	AKR1B1, ALOX12, CDK1, CSNK2A1, FLT3, HIF1A, IGF1R, KDR, MMP12, PIM1, THPO
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	3.893E-06	9.419E-04	ACHE, AHR, AKR1B1, APEX1, AURKB, BLM, CA4, CDK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, ESR2, FLT3, GLO1, HIF1A, HSD17B10, IGF1R, KDR, L3MBTL1, LMNA, MMP12, NOX4, PIM1, POLB, RECQL, TDP1, TOP2A, TYR, XDH
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	4.544E-06	1.010E-03	AKR1B1, CYP19A1, CYP1A2, NOX4, XDH
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	5.071E-06	1.104E-03	APEX1, POLB
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	5.178E-06	1.116E-03	AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1
BP	GO:0032502; developmental process	GO:0007568; aging	1.323E-05	2.528E-03	APEX1, AURKB, CDK1, CYP1A1, NOX4, POLB
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.519E-05	2.803E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.892E-05	3.349E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	2.666E-05	4.465E-03	AXL, CDK1, CSNK2A1, FLT3
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.034E-05	4.930E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.034E-05	4.930E-03	CYP1A2, CYP2C9
BP	GO:0008152; metabolic process	GO:0022900; electron transport chain	3.252E-05	5.169E-03	AKR1B1, CYP19A1, CYP1A2, NOX4, XDH
MF	GO:0005488; binding	GO:0000166; nucleotide binding	3.594E-05	5.622E-03	AURKB, AXL, BLM, CDK1, CSNK2A1, FLT3, HSD17B1, IGF1R, KDR, MET, NOX4, PIM1, RECQL, TOP2A, XDH
BP	GO:0002376; immune system process	GO:0030097; hemopoiesis	4.965E-05	7.457E-03	FLT3, HIF1A, KDR, L3MBTL1
MF	GO:0003824; catalytic activity	GO:0009378; four-way junction helicase activity	5.049E-05	7.479E-03	BLM, RECQL
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	6.283E-05	9.001E-03	AXL, FLT3, IGF1R, KDR, MET

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.175E-09	1.070E-07	HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.955E-09	1.345E-07	HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.458E-08	7.457E-07	CYP2C9, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.585E-06	2.404E-05	CBR1, AKR1B1, ALOX12, CYP2C19, TYR, CYP19A1, HSD17B10, CYP2C9, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.479E-07	9.972E-06	CYP2C9, CBR1, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.036E-05	1.346E-04	CYP2C9, CBR1, ALOX12, CYP2C19
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.748E-08	1.080E-06	CA12, CA2, CA4, CA7
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	9.273E-05	8.438E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.488E-05	3.967E-04	CYP2C9, CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	4.314E-04	3.271E-03	FLT3, MET, HIF1A
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.945E-04	3.264E-03	CYP2C9, CYP1A2, CYP1A1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.018E-03	6.176E-03	KDR, HIF1A, MET, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.703E-04	3.292E-03	CYP2C9, CYP1A2, CYP2C19
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	5.775E-04	3.754E-03	CSNK2A1, MET, IGF1R
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.162E-03	6.609E-03	CA2, CA4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.710E-05	4.763E-04	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12; CBR1;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	HIV infections	NA	AHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; CSNK2A1; FLT3; ACHE; HIF1A;
NA: NA	Upper abdominal bloating	NA	ACHE;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
NA: NA	Edema	NA	CA2;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1; XDH;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1; TYR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; AKR1B1;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
I00-I99: Diseases of the circulatory system	Heart failure	I50	XDH;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; AKR1B1;
NA: NA	GIST	NA	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
C00-D49: Neoplasms	Solid tumours	C00-D48	TOP2A; MET; AURKB; IGF1R; KDR; FLT3; HIF1A;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases