Plant Name: Iodes cirrhosa
Taxonomic Information:
Plant ID: NPO21454
Plant Latin Name: Iodes cirrhosa
Taxonomy Genus: Iodes
Taxonomy Family: Icacinaceae
Plant External Links:
NCBI TaxonomyDB:
1705841
Plant-of-the-World-Online:
607936-1
Used in Medicines:
Unknown.
Geographical Distribution:
Myanmar; Philippines; Indonesia; India; Vietnam; Laos; Thailand
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| FYN; LCK; MAPK1; MAPK14; | |
| CA2; CA12; CA7; | |
| NR1H4; | |
| L3MBTL1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 5 | TBXAS1 | Thromboxane-A synthase | P24557 | CHEMBL1835 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Kinase | FYN | Tyrosine-protein kinase FYN | P06241 | CHEMBL1841 |
| Protein Kinase | LCK | Tyrosine-protein kinase LCK | P06239 | CHEMBL258 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Kinase | MAPK14 | MAP kinase p38 alpha | Q16539 | CHEMBL260 |
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 6.228E-08 | 6.643E-04 | CA12, CA2, CA7 |
| MF | GO:0005488; binding | GO:0042610; CD8 receptor binding | 2.948E-07 | 1.605E-03 | FYN, LCK |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 8.842E-07 | 2.349E-03 | CA2, CA7 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 9.709E-07 | 2.349E-03 | CA12, CA2, CA7 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.797E-06 | 3.556E-03 | CA12, CA2, CA7 |
| BP | Unclassified; | GO:2000021; regulation of ion homeostasis | 4.063E-06 | 6.320E-03 | CA2, CA7, FYN, LCK |
| MF | GO:0005488; binding | GO:0042608; T cell receptor binding | 6.182E-06 | 7.478E-03 | FYN, LCK |
| MF | GO:0005488; binding | GO:0042609; CD4 receptor binding | 6.182E-06 | 7.478E-03 | FYN, LCK |
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09151 Immune system | hsa04660 | T cell receptor signaling pathway | 2.214E-07 | 1.273E-05 | LCK, MAPK1, FYN, MAPK14 |
| 09150 Organismal Systems | 09151 Immune system | hsa04611 | Platelet activation | 4.207E-07 | 1.613E-05 | TBXAS1, MAPK1, FYN, MAPK14 |
| 09150 Organismal Systems | 09158 Development | hsa04380 | Osteoclast differentiation | 5.772E-07 | 1.659E-05 | LCK, MAPK1, FYN, MAPK14 |
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 8.381E-08 | 9.638E-06 | CA12, CA2, CA7 |
| 09150 Organismal Systems | 09151 Immune system | hsa04664 | Fc epsilon RI signaling pathway | 6.083E-06 | 1.399E-04 | MAPK1, FYN, MAPK14 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 3.356E-05 | 6.432E-04 | MAPK1, FYN, MAPK14 |
| 09150 Organismal Systems | 09151 Immune system | hsa04650 | Natural killer cell mediated cytotoxicity | 4.770E-05 | 7.837E-04 | LCK, MAPK1, FYN |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 4.944E-04 | 5.366E-03 | MAPK1, MAPK14 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05020 | Prion diseases | 1.620E-04 | 2.329E-03 | MAPK1, FYN |
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 4.317E-04 | 5.366E-03 | MAPK1, MAPK14 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 6.883E-04 | 5.366E-03 | MAPK1, MAPK14 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 7.075E-04 | 5.366E-03 | MAPK1, MAPK14 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 5.613E-04 | 5.366E-03 | MAPK1, MAPK14 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 6.694E-04 | 5.366E-03 | CA2, NR1H4 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 7.269E-04 | 5.366E-03 | MAPK1, FYN |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.348E-03 | 7.383E-03 | MAPK1, MAPK14 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04912 | GnRH signaling pathway | 1.097E-03 | 7.005E-03 | MAPK1, MAPK14 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04914 | Progesterone-mediated oocyte maturation | 1.270E-03 | 7.383E-03 | MAPK1, MAPK14 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 7.466E-04 | 5.366E-03 | MAPK1, MAPK14 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04723 | Retrograde endocannabinoid signaling | 1.348E-03 | 7.383E-03 | MAPK1, MAPK14 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 1.625E-03 | 7.475E-03 | MAPK1, FYN |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05132 | Salmonella infection | 9.802E-04 | 6.630E-03 | MAPK1, MAPK14 |
| 09150 Organismal Systems | 09151 Immune system | hsa04620 | Toll-like receptor signaling pathway | 1.483E-03 | 7.417E-03 | MAPK1, MAPK14 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04668 | TNF signaling pathway | 1.596E-03 | 7.475E-03 | MAPK1, MAPK14 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05142 | Chagas disease (American trypanosomiasis) | 1.429E-03 | 7.417E-03 | MAPK1, MAPK14 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 1.833E-03 | 8.073E-03 | MAPK1, MAPK14 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 1.895E-03 | 8.073E-03 | MAPK1, MAPK14 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 2.321E-03 | 8.897E-03 | MAPK1, MAPK14 |
| 09150 Organismal Systems | 09158 Development | hsa04360 | Axon guidance | 2.119E-03 | 8.705E-03 | MAPK1, FYN |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04068 | FoxO signaling pathway | 2.321E-03 | 8.897E-03 | MAPK1, MAPK14 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04072 | Phospholipase D signaling pathway | 2.713E-03 | 9.574E-03 | MAPK1, FYN |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 2.640E-03 | 9.574E-03 | MAPK1, MAPK14 |
| 09150 Organismal Systems | 09153 Circulatory system | hsa04261 | Adrenergic signaling in cardiomyocytes | 2.863E-03 | 9.685E-03 | MAPK1, MAPK14 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 2.747E-03 | 9.574E-03 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| NA: NA | Edema | NA | CA2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | LCK; |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; |
| I00-I99: Diseases of the circulatory system | Coronary artery disease | I20-I25 | MAPK14; |
| N00-N99: Diseases of the genitourinary system | Nephritis | N00-N19, N25-N29 | TBXAS1; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | MAPK14; |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | TBXAS1; |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2; |
| I00-I99: Diseases of the circulatory system | Thromboembolism | I80-I82 | TBXAS1; |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | TBXAS1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MAPK1; MAPK14; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MAPK1; |
| I00-I99: Diseases of the circulatory system | Cardiac arrhythmias | I47-I49 | TBXAS1; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | MAPK14; |
| J00-J99: Diseases of the respiratory system | Acute lung injury | J80 | MAPK14; |
| NA: NA | Rheumatold arthritis | NA | MAPK14; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | MAPK14; |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | MAPK14; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1; |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; |
| NA: NA | Acute respiratory distress syndrome | NA | MAPK14; |
| I00-I99: Diseases of the circulatory system | Acute coronary syndrome | I74 | MAPK14; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | TBXAS1; |
| H00-H59: Diseases of the eye and adnexa | Diabetic retinopathy | H36, E10.3, E11.3, E13.3 | MAPK14; |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | MAPK14; TBXAS1; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MAPK14; |
| NA: NA | Inflammatory diseases | NA | MAPK14; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2; |
| I00-I99: Diseases of the circulatory system | Angina pectoris | I20 | TBXAS1; |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2; |
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
