CMAUP Plant Collective Molecular Activities

Plant Name: Thalictrum simplex

Taxonomic Information:

Plant ID: NPO21451
Plant Latin Name: Thalictrum simplex
Taxonomy Genus: Thalictrum
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: 495765
Plant-of-the-World-Online: 304708-2

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Ukraine; Hungary; Belarus; Italy; Denmark; Poland; Finland; Romania; France; Switzerland; Austria; China; Greece; Sweden; Germany; Norway; Russia; Bulgaria

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family C GPCR)	GRM5; GRM1;
Enzyme_unclassified	TDP1; BLM; ALDH1A1;
Hydrolase	GAA;
Metallo protease	FOLH1;
Transcription Factor	NFKB1;
SLC superfamily of solute carriers	SLC7A11;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Metallo protease	FOLH1	Glutamate carboxypeptidase II	Q04609	CHEMBL1892
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
SLC superfamily of solute carriers	SLC7A11	Cystine/glutamate transporter	Q9UPY5	CHEMBL1075149
Small molecule receptor (family C GPCR)	GRM5	Metabotropic glutamate receptor 5	P41594	CHEMBL3227
Small molecule receptor (family C GPCR)	GRM1	Metabotropic glutamate receptor 1	Q13255	CHEMBL3772
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	Unclassified;	GO:0099566; regulation of postsynaptic cytosolic calcium ion concentration	1.463E-06	1.062E-02	GRM1, GRM5
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.463E-06	1.062E-02	CYP2D6, CYP3A4
MF	GO:0060089; molecular transducer activity	GO:0099583; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	1.463E-06	1.062E-02	GRM1, GRM5
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	7.305E-06	3.977E-02	CYP2D6, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.229E-04	2.470E-02	ALDH1A1, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	9.514E-04	2.470E-02	GRM5, GRM1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.039E-03	2.470E-02	CYP2D6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.162E-03	2.470E-02	CYP2D6, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	2.209E-03	3.129E-02	GRM5, GRM1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	1.683E-03	2.861E-02	GRM5, GRM1
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	2.802E-03	3.403E-02	GRM5, GRM1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	4.190E-03	4.180E-02	LMNA, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04072	Phospholipase D signaling pathway	4.426E-03	4.180E-02	GRM5, GRM1
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	6.827E-03	5.275E-02	GRM5, GRM1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	GRM1; GRM5;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6; GRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
G00-G99: Diseases of the nervous system G00-G99	Chronic neuropathic pain	G64, G90.0, K21, R52, G89	GRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	GRM1;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	GRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Autism	F84.0	GRM5;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	GRM1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Fragile X syndrome	F02.3, G20, Q99.2	GRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	GRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	GRM1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	GRM5;
NA: NA	GERD	NA	GRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; GRM5;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	GRM1; GRM5;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	GRM1; GRM5;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases