CMAUP Plant Collective Molecular Activities

Plant Name: Populus balsamifera

Taxonomic Information:

Plant ID: NPO21410
Plant Latin Name: Populus balsamifera
Taxonomy Genus: Populus
Taxonomy Family: Salicaceae

Plant External Links:

NCBI TaxonomyDB: 73824
Plant-of-the-World-Online: 776600-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Anodyne; Antiinflammatory; Antiscorbutic; Antiseptic; Cathartic; Diuretic; Expectorant; Febrifuge; Stimulant; Tonic

Geographical Distribution:

Belgium; Canada; United States; China; France

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	MAPK1;
Unclassified	NPC1; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0071276; cellular response to cadmium ion	1.493E-05	1.280E-01	CYP1A2, MAPK1
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	7.080E-05	2.569E-01	MAPK1, MAPT
BP	GO:0007610; behavior	GO:0007610; behavior	8.511E-05	2.615E-01	MAPK1, MAPT, NPC1
BP	GO:0009987; cellular process	GO:1900034; regulation of cellular response to heat	9.608E-05	2.615E-01	MAPK1, MAPT
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	2.064E-04	3.469E-01	CYP1A2, MAPK1, NPC1
MF	GO:0005488; binding	GO:0019902; phosphatase binding	4.251E-04	5.143E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0030424; axon	1.040E-03	5.659E-01	MAPK1, MAPT
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	8.281E-04	5.659E-01	CYP1A2
CC	GO:0016020; membrane	GO:0045121; membrane raft	1.348E-03	6.053E-01	MAPK1, NPC1
MF	GO:0005488; binding	GO:0034452; dynactin binding	2.276E-03	6.884E-01	MAPT
MF	Unclassified;	GO:0004707; MAP kinase activity	2.896E-03	7.303E-01	MAPK1
MF	Unclassified;	GO:0004708; MAP kinase kinase activity	3.103E-03	7.303E-01	MAPK1
MF	GO:0003824; catalytic activity	GO:0008353; RNA polymerase II carboxy-terminal domain kinase activity	3.309E-03	7.303E-01	MAPK1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	4.162E-04	3.199E-02	MAPK1, MAPT
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	9.553E-04	3.199E-02	MAPK1, MAPT
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	9.997E-04	3.199E-02	CYP1A2
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.432E-02	3.441E-02	MAPK1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	1.452E-02	3.441E-02	MAPK1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.452E-02	3.441E-02	MAPK1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.373E-02	3.441E-02	CYP1A2
09130 Environmental Information Processing	09132 Signal transduction	hsa04350	TGF-beta signaling pathway	1.670E-02	3.441E-02	MAPK1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.472E-02	3.441E-02	MAPK1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.452E-02	3.441E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases