CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	PLK1;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Protein Kinase	PLK1	Serine/threonine-protein kinase PLK1	P53350	CHEMBL3024
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0043252; sodium-independent organic anion transport	6.074E-06	3.805E-02	SLCO1B1, SLCO1B3
BP	GO:0051179; localization	GO:0015721; bile acid and bile salt transport	6.989E-06	3.805E-02	SLCO1B1, SLCO1B3
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	2.749E-04	4.989E-01	SLCO1B1, SLCO1B3
CC	GO:0043226; organelle	GO:0051233; spindle midzone	4.807E-03	1.000E+00	PLK1
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	2.459E-06	3.805E-02	SLCO1B1, SLCO1B3
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	4.435E-06	3.805E-02	SLCO1B1, SLCO1B3

Showing 1 to 6 of 6 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	1.982E-02	1.982E-02	PLK1
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	1.834E-02	1.982E-02	PLK1
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	1.849E-02	1.982E-02	PLK1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.719E-05	1.860E-04	SLCO1B1, SLCO1B3
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1.463E-02	1.982E-02	PLK1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Nigella glandulifera

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities