CMAUP Plant Collective Molecular Activities

Plant Name: Eupatorium fortunei

Taxonomic Information:

Plant ID: NPO21343
Plant Latin Name: Eupatorium fortunei
Taxonomy Genus: Eupatorium
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 330892
Plant-of-the-World-Online: 205930-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

South Africa; Japan; India; Vietnam; China; Laos; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Transient receptor potential channel	TRPA1;
Lyase	CA2; CA1;
Oxidoreductase	PTGS1;
Enzyme_unclassified	ALDH1A1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A6; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.250E-06	4.899E-02	CA1, CA2
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	9.886E-06	6.845E-02	CYP2A6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	1.554E-05	6.845E-02	CYP2A6, CYP3A4, PTGS1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.572E-05	6.845E-02	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0016712; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	4.854E-05	1.174E-01	CYP2A6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	8.365E-05	1.821E-01	CYP2A6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	9.390E-05	1.859E-01	CA1, CA2
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.408E-04	2.358E-01	CA1, CA2
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	2.125E-04	3.200E-01	CYP2A6, PTGS1
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	2.795E-04	3.758E-01	ALDH1A1, CYP2A6, CYP3A4, PTGS1
BP	GO:0008152; metabolic process	GO:0044255; cellular lipid metabolic process	3.716E-04	3.758E-01	ALDH1A1, CYP2A6, CYP3A4, PTGS1
CC	GO:0044464; cell part	GO:0032421; stereocilium bundle	2.069E-03	6.008E-01	TRPA1
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	5.052E-03	1.000E+00	CYP2A6, CYP3A4, PTGS1
CC	GO:0016020; membrane	GO:0031090; organelle membrane	1.702E-02	1.000E+00	CYP2A6, CYP3A4, LMNA, PTGS1
CC	GO:0044421; extracellular region part	GO:0070062; extracellular exosome	1.917E-02	1.000E+00	ALDH1A1, CA1, CA2, PTGS1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.814E-06	4.353E-05	CYP2A6, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.436E-04	1.149E-03	CYP2A6, CYP3A4
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.898E-05	2.278E-04	CA1, CA2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.241E-04	1.451E-03	CYP2A6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.627E-04	1.451E-03	CYP2A6, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.431E-04	1.451E-03	CA2, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	8.386E-04	2.516E-03	CYP2A6, ALDH1A1, CYP3A4, PTGS1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.576E-04	1.569E-03	CYP2A6, CYP3A4
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	9.165E-03	2.200E-02	CA2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.999E-03	5.330E-03	CYP2A6

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases