CMAUP Plant Collective Molecular Activities

Plant Name: Lebeckia plukenetiana

Taxonomic Information:

Plant ID: NPO2128
Plant Latin Name: Lebeckia plukenetiana
Taxonomy Genus: Lebeckia
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 508252
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	CDK6;
Lyase	CA2; CA1; CA7; CA4; CA12; CA9;
Enzyme_unclassified	HSD17B10; CBR1; AKR1B1;
Transcription Factor	HIF1A;
ATP-binding cassette	ABCG2;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP3A4; CYP19A1; CYP2C9; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Protein Kinase	CDK6	Cyclin-dependent kinase 6	Q00534	CHEMBL2508
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.730E-14	1.256E-10	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.739E-13	7.573E-10	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.028E-12	3.731E-09	CA1, CA12, CA2, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.151E-12	6.692E-09	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4, XDH
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.707E-12	9.895E-09	CA1, CA12, CA2, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.252E-11	2.530E-08	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.394E-11	2.530E-08	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.302E-11	3.581E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	3.431E-11	4.669E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	4.114E-10	3.583E-07	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.794E-09	2.430E-06	CYP1A2, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	2.076E-07	1.027E-04	CYP1A2, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.659E-06	7.225E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	2.431E-06	9.987E-04	CYP19A1, CYP1A2, CYP3A4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.054E-06	1.146E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	3.054E-06	1.146E-03	CYP1A1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	4.179E-06	1.517E-03	AKR1B1, CYP19A1, CYP1A2, XDH
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	5.283E-06	1.826E-03	AKR1B1, CA2, CYP1A1, CYP1A2, CYP1B1, HIF1A
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	6.104E-06	2.014E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	1.017E-05	3.255E-03	CYP1A1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0016614; oxidoreductase activity, acting on CH-OH group of donors	1.044E-05	3.293E-03	AKR1B1, CBR1, HSD17B10, XDH
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.524E-05	4.546E-03	CYP1A1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.524E-05	4.546E-03	CA1, CA2
BP	GO:0008152; metabolic process	GO:0022900; electron transport chain	2.080E-05	6.121E-03	AKR1B1, CYP19A1, CYP1A2, XDH
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	2.132E-05	6.191E-03	CYP1A2, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	2.458E-05	6.861E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	2.841E-05	7.831E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0042446; hormone biosynthetic process	3.288E-05	8.949E-03	AKR1B1, CYP19A1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.676E-15	2.914E-11	CA1, CA12, CA2, CA4, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.365E-15	2.629E-13	CA12, CA1, CA2, CA4, CA7, CA9
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.113E-12	2.727E-11	CYP2C9, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.135E-11	1.165E-09	CYP2C9, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.578E-09	3.159E-08	CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
Unclassified	Unclassified	hsa01100	Metabolic pathways	8.374E-08	6.839E-07	CYP2C9, CBR1, CYP1A2, CYP1A1, AKR1B1, CYP2C19, CYP3A4, CYP19A1, HSD17B10, XDH
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.699E-08	1.665E-07	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.733E-07	3.313E-06	CYP2C9, CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.028E-07	3.692E-06	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	8.252E-06	4.493E-05	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.627E-05	7.246E-05	CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.115E-05	1.272E-04	CYP2C9, CBR1, CYP2C19
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.680E-05	1.764E-04	CA2, CYP3A4, ABCG2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	9.577E-04	3.128E-03	CYP3A4, XDH
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.374E-04	8.307E-04	CA2, CA4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	9.483E-06	4.647E-05	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	XDH;
I00-I99: Diseases of the circulatory system	Heart failure	I50	XDH;
J00-J99: Diseases of the respiratory system	Asthma	J45	CBR1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases