Plant Name: Aglaia elaeagnoidea
Taxonomic Information:
Plant ID: NPO21227
Plant Latin Name: Aglaia elaeagnoidea
Taxonomy Genus: Aglaia
Taxonomy Family: Meliaceae
Plant External Links:
NCBI TaxonomyDB:
201007
Plant-of-the-World-Online:
577065-1
Used in Medicines:
Unknown.
Geographical Distribution:
Australia; Bangladesh; Philippines; Indonesia; India; New Caledonia; Cambodia; Vietnam; Laos; Sri Lanka; Thailand; Taiwan; Vanuatu
Geographical Distribution
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See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPR35; | |
| NPSR1; | |
| TDP1; BLM; RECQL; GLO1; HPGD; AKR1B10; ALOX12; HSD17B1; AKR1B1; HSD17B10; NOX4; APEX1; POLB; | |
| CDC25B; | |
| ACHE; | |
| TOP2A; | |
| TEK; KDR; MET; AXL; FLT3; CDK1; EGFR; PIM1; NUAK1; INSR; SRC; IGF1R; AURKB; CSNK2A1; | |
| CA12; CA7; CA4; | |
| PPARA; | |
| RORC; | |
| ESR2; ESR1; | |
| NR1H4; | |
| KDM4E; | |
| F10; F2; | |
| BACE1; | |
| MMP12; | |
| HIF1A; | |
| FUT7; | |
| SLC22A6; | |
| SMAD3; LMNA; FABP5; HSPA1A; | |
| L3MBTL1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
Showing 1 to 10 of 55 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 1.088E-08 | 4.084E-06 | AXL, EGFR, F10, INSR, MET, NOX4, SRC, TEK |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 2.176E-07 | 4.738E-05 | EGFR, IGF1R, INSR, KDR, SRC |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 6.250E-07 | 1.106E-04 | ESR1, ESR2, NR1H4, PIM1, PPARA, RORC, SRC |
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 6.624E-07 | 1.127E-04 | CYP1A1, HIF1A, LMNA, NOX4, PPARA, SMAD3, SRC, TEK |
| BP | GO:0009987; cellular process | GO:0070301; cellular response to hydrogen peroxide | 8.188E-07 | 1.351E-04 | AKR1B1, APEX1, AXL, CDK1, CYP1B1 |
| BP | GO:0048511; rhythmic process | GO:0048511; rhythmic process | 1.324E-06 | 2.017E-04 | AXL, CSNK2A1, EGFR, ESR1, PPARA, RORC, SRC, TOP2A |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 1.831E-06 | 2.694E-04 | ESR1, ESR2, NR1H4, PPARA, RORC, SRC |
| BP | GO:0032502; developmental process | GO:0031100; animal organ regeneration | 2.462E-06 | 3.330E-04 | AXL, CDK1, CSNK2A1, EGFR, FLT3 |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 6.095E-06 | 7.253E-04 | CDK1, ESR1, ESR2, NR1H4, PPARA, RORC |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 6.177E-06 | 7.310E-04 | AKR1B1, AKR1B10, CYP1A1, CYP1B1, ESR1, HSD17B1, NR1H4 |
Showing 1 to 10 of 60 entries
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 5.455E-04 | 5.066E-03 | HSD17B1, CYP1A1, CYP1B1 |
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 1.302E-05 | 2.116E-04 | CA12, CA4, CA7 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 1.739E-06 | 5.653E-05 | SRC, INSR, KDR, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 9.315E-06 | 1.730E-04 | INSR, TEK, HIF1A, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 3.646E-05 | 4.740E-04 | INSR, KDR, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 3.372E-04 | 3.653E-03 | INSR, KDR, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04068 | FoxO signaling pathway | 4.902E-04 | 4.902E-03 | SMAD3, INSR, EGFR, IGF1R |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.250E-09 | 1.625E-07 | SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04144 | Endocytosis | 6.726E-06 | 1.663E-04 | SMAD3, SRC, KDR, MET, EGFR, HSPA1A, IGF1R |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04510 | Focal adhesion | 2.309E-04 | 2.729E-03 | SRC, KDR, MET, EGFR, IGF1R |
Showing 1 to 10 of 21 entries
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3; |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Trematode infection | B66.9 | ESR1; |
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR; |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE; |
| C00-D49: Neoplasms | Hormone refractory prostate cancer | C61 | ESR1; |
| C00-D49: Neoplasms | Esophageal cancer | C15 | EGFR; |
| C00-D49: Neoplasms | Refractory breast cancer | C50 | EGFR; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | KDR; |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR; |
Showing 1 to 10 of 194 entries
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
