CMAUP Plant Collective Molecular Activities

Plant Name: Kalopanax septemlobus

Taxonomic Information:

Plant ID: NPO21166
Plant Latin Name: Kalopanax septemlobus
Taxonomy Genus: Kalopanax
Taxonomy Family: Araliaceae

Plant External Links:

NCBI TaxonomyDB: 228393
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Korea

Traditional Medicine System:

Medicinal Functions:

Antifungal; Expectorant; Hepatic; Skin; Stomachic

Geographical Distribution:

South Korea

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALOX15; AKR1B10; AKR1B1;
Cysteine protease	CASP7; CASP1;
Transcription Factor	HIF1A;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	2.549E-06	1.371E-02	CASP1, CASP7, XDH
BP	GO:0008152; metabolic process	GO:0044597; daunorubicin metabolic process	3.149E-06	1.371E-02	AKR1B1, AKR1B10
BP	GO:0008152; metabolic process	GO:0044598; doxorubicin metabolic process	3.149E-06	1.371E-02	AKR1B1, AKR1B10
MF	GO:0003824; catalytic activity	GO:0097200; cysteine-type endopeptidase activity involved in execution phase of apoptosis	8.764E-06	2.120E-02	CASP1, CASP7
MF	GO:0003824; catalytic activity	GO:0016614; oxidoreductase activity, acting on CH-OH group of donors	1.170E-05	2.317E-02	AKR1B1, AKR1B10, XDH
MF	GO:0003824; catalytic activity	GO:0004033; aldo-keto reductase (NADP) activity	3.644E-05	4.667E-02	AKR1B1, AKR1B10
CC	GO:0044464; cell part	GO:0005829; cytosol	6.172E-05	5.376E-02	AKR1B1, AKR1B10, ALOX15, CASP1, CASP7, HIF1A, XDH
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	2.461E-04	1.307E-01	AKR1B1, HIF1A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6.578E-05	6.797E-04	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	4.546E-05	6.797E-04	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5.182E-05	6.797E-04	AKR1B10, AKR1B1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.546E-04	1.103E-03	CASP7, CASP1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	1.780E-04	1.103E-03	AKR1B10, AKR1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.409E-04	1.953E-03	AKR1B10, ALOX15, AKR1B1, XDH
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	2.879E-04	1.487E-03	CASP7, CASP1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.011E-02	3.481E-02	ALOX15
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.322E-02	4.234E-02	HIF1A
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.749E-03	6.777E-03	XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases