Plant Name: Phagnalon atlanticum
Taxonomic Information:
Plant ID: NPO21165
Plant Latin Name: Phagnalon atlanticum
Taxonomy Genus: Phagnalon
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 8.038E-07 | 1.750E-02 | CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 2.410E-06 | 2.565E-02 | CYP2C19, CYP2C9 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 3.534E-06 | 2.565E-02 | CYP2C19, CYP2C9 |
| MF | GO:0003824; catalytic activity | GO:0008392; arachidonic acid epoxygenase activity | 7.279E-06 | 2.972E-02 | CYP2C19, CYP2C9 |
| MF | GO:0005215; transporter activity | GO:0015125; bile acid transmembrane transporter activity | 8.188E-06 | 2.972E-02 | SLCO1B1, SLCO1B3 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.124E-05 | 3.495E-02 | CYP2C19, CYP2C9 |
| MF | GO:0005215; transporter activity | GO:0015347; sodium-independent organic anion transmembrane transporter activity | 1.476E-05 | 4.018E-02 | SLCO1B1, SLCO1B3 |
| BP | GO:0051179; localization | GO:0043252; sodium-independent organic anion transport | 2.021E-05 | 4.889E-02 | SLCO1B1, SLCO1B3 |
| BP | GO:0051179; localization | GO:0015721; bile acid and bile salt transport | 2.325E-05 | 5.063E-02 | SLCO1B1, SLCO1B3 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 2.997E-05 | 5.933E-02 | CYP2C19, CYP2C9 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 5.283E-05 | 8.850E-02 | CYP2C19, CYP2C9 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 4.301E-04 | 3.658E-01 | CYP2C19, CYP2C9 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 9.049E-04 | 5.473E-01 | SLCO1B1, SLCO1B3 |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 4.149E-02 | 1.000E+00 | LMNA |
| CC | GO:0044425; membrane part | GO:0005887; integral component of plasma membrane | 4.584E-02 | 1.000E+00 | SLCO1B1, SLCO1B3 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.025E-05 | 2.632E-04 | CYP2C9, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 9.399E-05 | 4.011E-04 | CYP2C9, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.165E-04 | 4.011E-04 | CYP2C9, CYP2C19 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.234E-04 | 4.011E-04 | SLCO1B1, SLCO1B3 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 3.074E-04 | 6.661E-04 | CYP2C9, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.647E-04 | 4.283E-04 | CYP2C9, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.812E-02 | 2.636E-02 | CYP2C9 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.837E-02 | 2.636E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 2.230E-02 | 2.636E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 2.058E-02 | 2.636E-02 | LMNA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
