CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2C; HRH3; ADRA2A;
Peptide receptor (family A GPCR)	TSHR;
Nuclear hormone receptor subfamily 3 group C	NR3C1;
Transcription Factor	NFKB1; HIF1A;
Plant homeodomain	KMT2A;
Unclassified	MAPT; SERPINA6;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group C	NR3C1	Glucocorticoid receptor	P04150	CHEMBL2034
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	HRH3	Histamine H3 receptor	Q9Y5N1	CHEMBL264
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Showing 1 to 10 of 11 entries

Previous1 2Next

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	2.121E-06	7.199E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	2.121E-06	7.199E-03	ADRA2A, ADRA2C
BP	GO:0065007; biological regulation	GO:0045761; regulation of adenylate cyclase activity	2.561E-06	7.199E-03	ADRA2A, HRH3, TSHR
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	8.466E-06	1.121E-02	ADRA2A, ADRA2C, HIF1A, NFKB1, SERPINA6
BP	GO:0009987; cellular process	GO:0010700; negative regulation of norepinephrine secretion	9.886E-06	1.121E-02	ADRA2A, ADRA2C
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	2.327E-05	1.635E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	2.749E-05	1.710E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	5.383E-05	2.494E-02	SMN1, SMN2
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	8.994E-07	5.776E-03	HIF1A, MAPT, NR3C1
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.061E-06	5.776E-03	ADRA2A, ADRA2C

Showing 1 to 10 of 13 entries

Previous1 2Next

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	4.586E-03	6.614E-02	SMN2, SMN1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3.596E-07	2.373E-05	HRH3, ADRA2C, NR3C1, ADRA2A, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.676E-03	5.531E-02	HIF1A, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	4.330E-03	6.614E-02	ADRA2C, ADRA2A
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	6.089E-03	6.697E-02	NFKB1, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	9.824E-03	9.262E-02	MAPT, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	4.179E-02	9.388E-02	TSHR
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	5.010E-03	6.614E-02	KMT2A, NFKB1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.274E-02	9.388E-02	HIF1A, NFKB1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	4.294E-02	9.388E-02	NFKB1

Showing 1 to 10 of 10 entries

Previous1Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	NR3C1; SERPINA6;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; HIF1A; NR3C1;
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Obese insulin-resistant disorders	E11	HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C; HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic macular edema	E08-E13, E08.3, E09.3, E10.3, E11.3, E13.3, H35.8, R60.9	SERPINA6;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C;

Showing 1 to 10 of 67 entries

Previous1 2 3 4 5 6 7Next

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Anisocycla grandidieri

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities