Plant Name: Eurycoma sp.
Taxonomic Information:
Plant ID: NPO20997
Plant Latin Name: Eurycoma sp.
Taxonomy Genus: Eurycoma
Taxonomy Family: Simaroubaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 2.354E-13 | 5.126E-09 | CA1, CA12, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.016E-11 | 1.106E-07 | CA1, CA12, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 2.341E-11 | 1.699E-07 | CA1, CA12, CA7, CA9 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 3.116E-06 | 7.539E-03 | CA1, CA12, CA7, CA9 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 6.212E-04 | 9.661E-01 | CA7 |
| BP | GO:0009987; cellular process | GO:0043620; regulation of DNA-templated transcription in response to stress | 2.421E-02 | 1.000E+00 | CA9 |
| BP | GO:0023052; signaling | GO:0050806; positive regulation of synaptic transmission | 2.482E-02 | 1.000E+00 | CA7 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 3.797E-02 | 1.000E+00 | CA9 |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 1.242E-03 | 1.000E+00 | CA1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 3.571E-13 | 3.571E-13 | CA12, CA1, CA7, CA9 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | CA9; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9; |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9; |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
