Plant Name: Wisteria brachybotrys
Taxonomic Information:
Plant ID: NPO20912
Plant Latin Name: Wisteria brachybotrys
Taxonomy Genus: Wisteria
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
185975
Plant-of-the-World-Online:
268990-2
Used in Medicines:
Unknown.
Geographical Distribution:
China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PRKCE; PRKCB; PRKCG; PRKCD; PRKCA; PRKCQ; | |
| TERT; | |
| TP53; | |
| MAPT; RAB9A; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Protein Kinase | PRKCE | Protein kinase C epsilon | Q02156 | CHEMBL3582 |
| Protein Kinase | PRKCB | Protein kinase C beta | P05771 | CHEMBL3045 |
| Protein Kinase | PRKCG | Protein kinase C gamma | P05129 | CHEMBL2938 |
| Protein Kinase | PRKCD | Protein kinase C delta | Q05655 | CHEMBL2996 |
| Protein Kinase | PRKCA | Protein kinase C alpha | P17252 | CHEMBL299 |
| Protein Kinase | PRKCQ | Protein kinase C theta | Q04759 | CHEMBL3920 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 1.006E-09 | 6.597E-06 | PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ |
| MF | GO:0003824; catalytic activity | GO:0004698; calcium-dependent protein kinase C activity | 1.212E-09 | 6.597E-06 | PRKCA, PRKCB, PRKCG |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 6.054E-09 | 2.197E-05 | CYP2C19, CYP2C9, CYP2D6 |
| BP | GO:0009987; cellular process | GO:0090330; regulation of platelet aggregation | 2.457E-07 | 4.865E-04 | PRKCA, PRKCD, PRKCQ |
| BP | GO:0008152; metabolic process | GO:0035408; histone H3-T6 phosphorylation | 4.878E-07 | 7.587E-04 | PRKCA, PRKCB |
| MF | GO:0003824; catalytic activity | GO:0035403; histone kinase activity (H3-T6 specific) | 4.878E-07 | 7.587E-04 | PRKCA, PRKCB |
| BP | GO:0050896; response to stimulus | GO:0046627; negative regulation of insulin receptor signaling pathway | 1.216E-06 | 1.558E-03 | PRKCB, PRKCD, PRKCQ |
| MF | GO:0003824; catalytic activity | GO:0004699; calcium-independent protein kinase C activity | 1.463E-06 | 1.702E-03 | PRKCD, PRKCE |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 1.790E-06 | 1.772E-03 | CYP2C19, CYP2C9, CYP2D6 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 4.224E-06 | 2.967E-03 | CYP2C19, CYP2C9, CYP2D6 |
| BP | GO:0051179; localization | GO:1903829; positive regulation of cellular protein localization | 6.374E-06 | 3.966E-03 | MAPT, PRKCD, PRKCE, TERT, TP53 |
| BP | GO:0009987; cellular process | GO:0034351; negative regulation of glial cell apoptotic process | 1.363E-05 | 5.705E-03 | PRKCA, PRKCD |
| BP | GO:0008152; metabolic process | GO:0031324; negative regulation of cellular metabolic process | 1.815E-05 | 6.822E-03 | CYP2D6, MAPT, NPC1, PRKCA, PRKCD, PRKCE, PRKCG, TERT, TP53 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 2.188E-05 | 7.940E-03 | CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 2.362E-05 | 8.163E-03 | CYP2C19, CYP2C9, CYP2D6, NPC1 |
| BP | GO:0007610; behavior | GO:0007610; behavior | 2.722E-05 | 8.954E-03 | MAPT, NPC1, PRKCE, PRKCG, TP53 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 3.206E-05 | 8.954E-03 | CYP2C19, CYP2C9 |
| BP | GO:0009987; cellular process | GO:0090399; replicative senescence | 3.206E-05 | 8.954E-03 | TERT, TP53 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 3.206E-05 | 8.954E-03 | CYP2C9, CYP2D6 |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 3.201E-05 | 8.954E-03 | PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ, TP53 |
| CC | GO:0044464; cell part | GO:0005783; endoplasmic reticulum | 2.871E-05 | 8.954E-03 | CYP2D6, NPC1, PRKCA, PRKCD, PRKCE, TP53 |
| BP | GO:0009987; cellular process | GO:0035556; intracellular signal transduction | 4.043E-05 | 9.828E-03 | PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ, TP53 |
| BP | GO:0002376; immune system process | GO:0002684; positive regulation of immune system process | 4.231E-05 | 9.995E-03 | PRKCA, PRKCB, PRKCD, PRKCE, PRKCQ, TP53 |
| CC | GO:0016020; membrane | GO:0016020; membrane | 6.359E-05 | 1.308E-02 | CYP2C19, CYP2C9, CYP2D6, MAPT, NPC1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ, RAB9A, TERT |
| CC | GO:0044464; cell part | GO:0048471; perinuclear region of cytoplasm | 6.463E-05 | 1.308E-02 | NPC1, PRKCA, PRKCD, PRKCE, PRKCG |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09157 Sensory system | hsa04750 | Inflammatory mediator regulation of TRP channels | 3.448E-11 | 3.586E-09 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, PRKCQ |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 7.799E-11 | 4.056E-09 | PRKCG, CYP2C9, CYP2D6, PRKCB, PRKCA, CYP2C19 |
| 09150 Organismal Systems | 09153 Circulatory system | hsa04270 | Vascular smooth muscle contraction | 1.188E-10 | 4.117E-09 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, PRKCQ |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04530 | Tight junction | 2.900E-10 | 7.541E-09 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, PRKCQ |
| 09150 Organismal Systems | 09151 Immune system | hsa04666 | Fc gamma R-mediated phagocytosis | 3.777E-09 | 7.856E-08 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 5.403E-08 | 8.027E-07 | PRKCG, PRKCB, PRKCA, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 9.923E-08 | 1.290E-06 | PRKCG, PRKCB, PRKCA, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 1.371E-08 | 2.376E-07 | PRKCG, PRKCB, PRKCE, PRKCA, TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04925 | Aldosterone synthesis and secretion | 2.423E-07 | 2.800E-06 | PRKCG, PRKCB, PRKCE, PRKCA |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 5.899E-07 | 5.583E-06 | PRKCB, PRKCE, PRKCD, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 5.905E-07 | 5.583E-06 | PRKCG, PRKCB, PRKCA, MAPT, TP53 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 8.011E-07 | 6.943E-06 | PRKCB, PRKCE, PRKCD, PRKCQ |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 1.253E-06 | 9.305E-06 | PRKCG, PRKCB, PRKCE, PRKCA, TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.101E-06 | 8.809E-06 | PRKCG, PRKCB, PRKCA, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04310 | Wnt signaling pathway | 2.307E-06 | 1.489E-05 | PRKCG, PRKCB, PRKCA, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 2.577E-06 | 1.489E-05 | PRKCG, PRKCB, PRKCA, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 9.525E-06 | 4.338E-05 | PRKCG, PRKCB, PRKCA, TP53 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04730 | Long-term depression | 9.126E-06 | 4.338E-05 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05143 | African trypanosomiasis | 1.764E-06 | 1.223E-05 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04150 | mTOR signaling pathway | 9.126E-06 | 4.338E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09155 Excretory system | hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 4.348E-06 | 2.380E-05 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 9.594E-06 | 4.338E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09155 Excretory system | hsa04960 | Aldosterone-regulated sodium reabsorption | 2.459E-06 | 1.489E-05 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09164 Substance dependence | hsa05031 | Amphetamine addiction | 1.274E-05 | 5.299E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04720 | Long-term potentiation | 1.217E-05 | 5.275E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04971 | Gastric acid secretion | 1.719E-05 | 6.384E-05 | PRKCG, PRKCB, PRKCA |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.392E-05 | 5.568E-05 | CYP2C9, CYP2D6, CYP2C19 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04911 | Insulin secretion | 2.607E-05 | 9.349E-05 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04012 | ErbB signaling pathway | 2.795E-05 | 9.402E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.517E-05 | 5.845E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04912 | GnRH signaling pathway | 3.199E-05 | 9.505E-05 | PRKCB, PRKCD, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04727 | GABAergic synapse | 2.893E-05 | 9.402E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04970 | Salivary secretion | 2.993E-05 | 9.431E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09159 Environmental adaptation | hsa04713 | Circadian entrainment | 3.638E-05 | 1.051E-04 | PRKCG, PRKCB, PRKCA |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04540 | Gap junction | 2.893E-05 | 9.402E-05 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09164 Substance dependence | hsa05032 | Morphine addiction | 3.199E-05 | 9.505E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04916 | Melanogenesis | 4.242E-05 | 1.082E-04 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04070 | Phosphatidylinositol signaling system | 3.993E-05 | 1.082E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 5.792E-05 | 1.369E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04723 | Retrograde endocannabinoid signaling | 4.370E-05 | 1.082E-04 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05231 | Choline metabolism in cancer | 4.370E-05 | 1.082E-04 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05146 | Amoebiasis | 4.242E-05 | 1.082E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04972 | Pancreatic secretion | 3.754E-05 | 1.055E-04 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.307E-04 | 2.719E-04 | PRKCG, PRKCB, PRKCA, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 4.633E-05 | 1.121E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04724 | Glutamatergic synapse | 6.272E-05 | 1.449E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04728 | Dopaminergic synapse | 9.059E-05 | 2.005E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09151 Immune system | hsa04650 | Natural killer cell mediated cytotoxicity | 1.037E-04 | 2.246E-04 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 1.060E-04 | 2.249E-04 | RAB9A, PRKCQ, TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04921 | Oxytocin signaling pathway | 1.652E-04 | 3.368E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09151 Immune system | hsa04670 | Leukocyte transendothelial migration | 6.950E-05 | 1.571E-04 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04020 | Calcium signaling pathway | 2.426E-04 | 4.760E-04 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 3.867E-04 | 7.313E-04 | PRKCG, PRKCB, PRKCA |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04510 | Focal adhesion | 3.404E-04 | 6.555E-04 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 4.788E-04 | 8.893E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 3.099E-03 | 5.199E-03 | PRKCD, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 1.877E-03 | 3.200E-03 | PRKCB, PRKCQ |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.464E-03 | 2.537E-03 | CYP2C9, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.162E-03 | 2.049E-03 | CYP2C9, CYP2D6 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 8.400E-04 | 1.506E-03 | CYP2C9, CYP2C19 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04930 | Type II diabetes mellitus | 5.039E-04 | 9.194E-04 | PRKCE, PRKCD |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.828E-04 | 3.655E-04 | CYP2C9, CYP2C19 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9; |
| C00-D49: Neoplasms | Central nervous system tumors | NA | PRKCB; |
| I00-I99: Diseases of the circulatory system | Acute myocardial infarction | I21-I22 | PRKCD; |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | PRKCE; |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | PRKCB; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Renal transplantation | D89.8 | PRKCB; |
| C00-D49: Neoplasms | Cancer | C00-C96 | PRKCB; |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | PRKCB; |
| NA: NA | Reperfusion injury and heart attacks | NA | PRKCD; |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | PRKCB; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | PRKCB; |
| I00-I99: Diseases of the circulatory system | Ischemic reperfusion injury | I00-I99 | PRKCE; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
