CMAUP Plant Collective Molecular Activities

Plant Name: Atractylodes macrocephala

Taxonomic Information:

Plant ID: NPO20902
Plant Latin Name: Atractylodes macrocephala
Taxonomy Genus: Atractylodes
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 265785
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Antibacterial; Diuretic; Sedative; Stomachic; Tonic

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4; GPR35;
Enzyme_unclassified	ALPL; TDP1; RECQL; HPGD; AKR1B1; NOX4; ALOX15; APEX1; POLB;
Protein Kinase	NUAK1; TEK; INSR; MET; FLT3; EGFR; SRC; KDR; IGF1R; CSNK2A1;
Lyase	CA2; CA12; CA9; CA14; CA7; CA4; CA1;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Lysine demethylase	KDM4E;
Metallo protease	MMP12;
Transcription Factor	HIF1A; NFKB1;
Transferase	FUT7;
SLC superfamily of solute carriers	SLC22A6;
Unclassified	SMAD3; LMNA; FABP3; FABP5; FABP4; HSPA1A;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Protein Kinase	NUAK1	NUAK family SNF1-like kinase 1	O60285	CHEMBL5784
Protein Kinase	TEK	Tyrosine-protein kinase TIE-2	Q02763	CHEMBL4128
Protein Kinase	INSR	Insulin receptor	P06213	CHEMBL1981
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	SRC	Tyrosine-protein kinase SRC	P12931	CHEMBL267
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
SLC superfamily of solute carriers	SLC22A6	Solute carrier family 22 member 6	Q4U2R8	CHEMBL1641347
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	GPR35	G-protein coupled receptor 35	Q9HC97	CHEMBL1293267
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	SMAD3	Mothers against decapentaplegic homolog 3	P84022	CHEMBL1293258
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	HSPA1A	Heat shock 70 kDa protein 1	P0DMV8	CHEMBL5460

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.133E-11	1.898E-08	CA1, CA12, CA14, CA2, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.747E-10	3.148E-07	CA1, CA12, CA2, CA4, CA7, CA9
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	8.165E-08	3.013E-05	AKR1B1, CSNK2A1, EGFR, FFAR4, HIF1A, HSPA1A, IGF1R, KDR, LMNA, NFKB1, SMAD3, SRC, TEK
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	9.735E-08	3.475E-05	EGFR, IGF1R, INSR, KDR, SRC
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	1.877E-07	5.966E-05	CYP1A1, HIF1A, LMNA, NOX4, PPARA, SMAD3, SRC, TEK
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.114E-07	9.042E-05	CA2, CA4, CA9, EGFR, HPGD, SLC22A6, TEK
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	4.594E-07	1.266E-04	ALOX15, EGFR, FFAR4, KDR, NOX4, SRC, TEK
MF	GO:0005488; binding	GO:0005504; fatty acid binding	5.182E-07	1.410E-04	FABP3, FABP4, FABP5, FFAR4
MF	Unclassified;	GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity	1.123E-06	2.746E-04	EGFR, INSR, KDR
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.601E-06	3.873E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	1.770E-06	4.213E-04	EGFR, INSR, MET, NOX4, SRC, TEK
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.260E-06	8.835E-04	CYP1A1, CYP1A2, CYP1B1, NOX4
BP	GO:0032502; developmental process	GO:0002009; morphogenesis of an epithelium	5.008E-06	9.913E-04	CA2, CA9, EGFR, HIF1A, MET, SMAD3, SRC
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	5.795E-06	1.117E-03	APEX1, POLB
BP	GO:0009987; cellular process	GO:0051495; positive regulation of cytoskeleton organization	7.458E-06	1.351E-03	ALOX15, HSPA1A, MET, NOX4, SMAD3, TEK
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	8.611E-06	1.512E-03	FFAR4, NFKB1, PPARA, SMAD3, TEK
BP	GO:0008152; metabolic process	GO:0070988; demethylation	1.269E-05	1.988E-03	APEX1, CYP1A1, CYP1A2, KDM4E
MF	GO:0005488; binding	GO:0020037; heme binding	1.450E-05	2.239E-03	CYP1A1, CYP1A2, CYP1B1, NOX4, SRC
MF	GO:0005488; binding	GO:0019838; growth factor binding	1.563E-05	2.347E-03	EGFR, IGF1R, INSR, KDR, TEK
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.736E-05	2.528E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.741E-05	2.528E-03	CYP1A1, CYP1A2, CYP1B1
MF	Unclassified;	GO:0032403; protein complex binding	1.710E-05	2.528E-03	APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, SMAD3, SRC
MF	GO:0005488; binding	GO:0044877; macromolecular complex binding	1.927E-05	2.690E-03	APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, SMAD3, SRC
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.311E-05	3.106E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.311E-05	3.106E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0071363; cellular response to growth factor stimulus	2.721E-05	3.506E-03	EGFR, INSR, KDR, NOX4, SMAD3, SRC
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	2.801E-05	3.570E-03	AKR1B1, CYP1A1, CYP1B1, EGFR, FFAR1, FFAR4, HIF1A, NFKB1
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.991E-05	3.752E-03	FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.466E-05	4.216E-03	CYP1A1, CYP1A2
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	3.655E-05	4.397E-03	ALOX15, EGFR, PPARA, SMAD3
BP	GO:0032501; multicellular organismal process	GO:0001819; positive regulation of cytokine production	4.405E-05	5.157E-03	CYP1B1, HIF1A, HSPA1A, MMP12, NFKB1, SMAD3, SRC
BP	GO:0008152; metabolic process	GO:0043552; positive regulation of phosphatidylinositol 3-kinase activity	5.235E-05	5.968E-03	FLT3, SRC, TEK
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	5.400E-05	6.092E-03	ALPL, CYP1A1, CYP1A2, HPGD, NFKB1, SRC
MF	GO:0003824; catalytic activity	GO:0016491; oxidoreductase activity	5.619E-05	6.268E-03	AKR1B1, ALOX15, APEX1, CYP1A1, CYP1A2, CYP1B1, HPGD, KDM4E, NOX4
BP	GO:0009987; cellular process	GO:1902905; positive regulation of supramolecular fiber organization	6.153E-05	6.568E-03	ALOX15, HSPA1A, MET, NOX4, SMAD3
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	6.373E-05	6.704E-03	CSNK2A1, HIF1A, KDR
BP	GO:0008283; cell proliferation	GO:0050679; positive regulation of epithelial cell proliferation	6.498E-05	6.770E-03	EGFR, HIF1A, KDR, MMP12, TEK
BP	GO:0008152; metabolic process	GO:1902893; regulation of pri-miRNA transcription from RNA polymerase II promoter	6.998E-05	7.155E-03	HIF1A, PPARA, SMAD3
BP	GO:0008152; metabolic process	GO:0010907; positive regulation of glucose metabolic process	6.998E-05	7.155E-03	INSR, PPARA, SRC
CC	GO:0016020; membrane	GO:0045121; membrane raft	7.368E-05	7.393E-03	EGFR, INSR, KDR, SLC22A6, SRC, TEK
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	8.638E-05	8.397E-03	ALOX15, HPGD
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	8.638E-05	8.397E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.006E-15	1.456E-11	CA1, CA12, CA14, CA2, CA4, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.737E-15	6.774E-13	CA12, CA1, CA2, CA4, CA7, CA9, CA14
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	3.967E-10	2.836E-08	SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.457E-07	6.946E-06	INSR, TEK, HIF1A, EGFR, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	5.790E-07	2.070E-05	SRC, INSR, KDR, TEK, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	9.457E-07	2.705E-05	INSR, KDR, TEK, MET, EGFR, NFKB1, IGF1R
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	2.277E-06	5.426E-05	SMAD3, SRC, KDR, MET, EGFR, HSPA1A, IGF1R
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	7.710E-06	1.378E-04	SRC, KDR, HIF1A, MET, EGFR, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	5.694E-06	1.163E-04	INSR, CYP1A1, CYP1B1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.378E-05	2.190E-04	INSR, KDR, TEK, MET, EGFR, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	3.653E-05	4.018E-04	SMAD3, FLT3, HIF1A, MET, EGFR, NFKB1, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1.952E-05	2.465E-04	SRC, MET, EGFR, NFKB1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.841E-05	2.465E-04	FLT3, MET, HIF1A, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.069E-05	2.465E-04	FABP3, FABP4, FABP5, PPARA
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	1.087E-04	1.010E-03	SRC, KDR, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	6.307E-05	6.443E-04	HPGD, FLT3, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	2.671E-04	2.247E-03	SMAD3, INSR, EGFR, IGF1R
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.131E-04	1.010E-03	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09149 Aging	hsa04213	Longevity regulating pathway - multiple species	4.583E-04	3.449E-03	INSR, HSPA1A, IGF1R
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	5.017E-04	3.587E-03	SMAD3, EGFR, NFKB1
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	6.215E-04	4.232E-03	MET, EGFR, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.428E-04	2.723E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.199E-03	7.143E-03	EGFR, NFKB1, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6.741E-04	4.382E-03	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.404E-03	7.720E-03	INSR, NFKB1, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.629E-03	8.627E-03	SRC, EGFR, HSPA1A
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	9.457E-04	5.880E-03	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.325E-03	7.580E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
K00-K95: Diseases of the digestive system	Crohn's disease	K50	INSR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Glioma	C71	KDR; EGFR;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	TEK;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	INSR; AKR1B1; FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperglycaemia in type 2 diabetes	E11, R73.9	INSR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	INSR;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hunter syndrome	E76.1	INSR;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR; TEK;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	INSR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	IGF1R; INSR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	SRC;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; EGFR; ALPL;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; EGFR;
C00-D49: Neoplasms	Osteosarcoma	C40-C41	SRC;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	SRC;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; EGFR;
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypoglycemia	E16.0-E16.2	INSR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; SRC;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; INSR; EGFR; CA9;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Gastric cancer	C16	KDR; EGFR;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	FLT3;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR;
C00-D49: Neoplasms	Breast cancer	C50	IGF1R; KDR; FLT3; INSR; EGFR; CA9;
C00-D49: Neoplasms	Brain cancer	C71, D33	EGFR; SRC;
C00-D49: Neoplasms	Renal cancer	C64	KDR; CA9;
C00-D49: Neoplasms	Advanced breast cancer	C50	SRC;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Bladder cancer	C67	EGFR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Cancer	C00-C96	MET; IGF1R; KDR; CSNK2A1; NFKB1; FLT3; HIF1A; TEK; EGFR; SRC; CA1; CA9;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	INSR;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
NA: NA	GIST	NA	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	INSR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR; EGFR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
C00-D49: Neoplasms	Chronic myelogenous leukaemia	C92.1	SRC;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; EGFR;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Urethral cancer	NA	EGFR;
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; IGF1R; KDR; FLT3; HIF1A; TEK; EGFR; SRC; CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; INSR; FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1/2 diabetes	E08-E13	INSR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; EGFR; AKR1B1;
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; EGFR;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3; EGFR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; EGFR;
C00-D49: Neoplasms	Melanoma	C43	KDR; EGFR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR;
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	TEK; SRC;
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR; SRC;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1; CA1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	INSR; FFAR1;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	EGFR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	INSR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases