CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Nuclear hormone receptor subfamily 1 group H	NR1H3;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 1 group H	NR1H3	LXR-alpha	Q13133	CHEMBL2808

Showing 1 to 1 of 1 entries

Previous1Next

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	3.106E-04	7.140E-01	NR1H3
BP	GO:0009987; cellular process	GO:0060336; negative regulation of interferon-gamma-mediated signaling pathway	3.106E-04	7.140E-01	NR1H3
CC	GO:0032991; macromolecular complex	GO:0090575; RNA polymerase II transcription factor complex	6.782E-03	1.000E+00	NR1H3
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	1.667E-02	1.000E+00	NR1H3
MF	GO:0140110; transcription regulator activity	GO:0000988; transcription factor activity, protein binding	3.174E-02	1.000E+00	NR1H3
MF	GO:0005488; binding	GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding	3.256E-02	1.000E+00	NR1H3
MF	GO:0140110; transcription regulator activity	GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding	3.945E-02	1.000E+00	NR1H3
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.209E-02	1.000E+00	NR1H3

Showing 1 to 8 of 8 entries

Previous1Next

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.450E-03	7.550E-03	NR1H3
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	5.450E-03	7.550E-03	NR1H3
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	7.550E-03	7.550E-03	NR1H3
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	6.650E-03	7.550E-03	NR1H3

Showing 1 to 4 of 4 entries

Previous1Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

Showing 0 to 0 of 0 entries

PreviousNext

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Coleonema pulchellum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities