Plant Name: Coleonema pulchellum
Taxonomic Information:
Plant ID: NPO20891
Plant Latin Name: Coleonema pulchellum
Taxonomy Genus: Coleonema
Taxonomy Family: Rutaceae
Plant External Links:
NCBI TaxonomyDB:
23551
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| NR1H3; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 1 group H | NR1H3 | LXR-alpha | Q13133 | CHEMBL2808 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 3.106E-04 | 7.140E-01 | NR1H3 |
| BP | GO:0009987; cellular process | GO:0060336; negative regulation of interferon-gamma-mediated signaling pathway | 3.106E-04 | 7.140E-01 | NR1H3 |
| CC | GO:0032991; macromolecular complex | GO:0090575; RNA polymerase II transcription factor complex | 6.782E-03 | 1.000E+00 | NR1H3 |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 1.667E-02 | 1.000E+00 | NR1H3 |
| MF | GO:0140110; transcription regulator activity | GO:0000988; transcription factor activity, protein binding | 3.174E-02 | 1.000E+00 | NR1H3 |
| MF | GO:0005488; binding | GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding | 3.256E-02 | 1.000E+00 | NR1H3 |
| MF | GO:0140110; transcription regulator activity | GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding | 3.945E-02 | 1.000E+00 | NR1H3 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 4.209E-02 | 1.000E+00 | NR1H3 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 3.450E-03 | 7.550E-03 | NR1H3 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 5.450E-03 | 7.550E-03 | NR1H3 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 7.550E-03 | 7.550E-03 | NR1H3 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 6.650E-03 | 7.550E-03 | NR1H3 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
