CMAUP Plant Collective Molecular Activities

Plant Name: Rheum officinale

Taxonomic Information:

Plant ID: NPO20881
Plant Latin Name: Rheum officinale
Taxonomy Genus: Rheum
Taxonomy Family: Polygonaceae

Plant External Links:

NCBI TaxonomyDB: 137220
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Jordan; Iraq; India; China

Traditional Medicine System:

Unani; TCM; Homeopathy; Ayurveda

Medicinal Functions:

Anticholesterolemic; Antiseptic; Antispasmodic; Antitumor; Aperient; Astringent; Cholagogue; Diuretic; Stomachic; Tonic

Geographical Distribution:

Jordan; India; Iraq; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR2C; ADORA3; HTR5A; HTR1F; HTR7; DRD3; HTR1B; DRD2; HTR4; HTR1D; HTR1E; HTR2B; HTR2A; HTR1A; HTR6;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	ALPL; TDP1; BLM; PIK3CA; PIK3CB; HSD11B1; HSD11B2; PGD; GFER; HSD17B10; NQO2; ALOX12; ALOX15; USP2; APEX1;
Hydrolase	ACHE;
Miscellaneous ion channel	BCL2;
5HT3 receptor	HTR3A;
Lyase	CA12; CA9; CA14; CA7;
Nuclear hormone receptor subfamily 3 group A	ESR1;
Nuclear hormone receptor subfamily 2 group B	RXRA;
Lysine demethylase	KDM4E;
Oxidoreductase	PTGS2;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	NFKB1;
Transferase	FUT7;
Unclassified	LMNA;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP3A4; CYP1B1; CYP1A1; CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
5HT3 receptor	HTR3A	Serotonin 3a (5-HT3a) receptor	P46098	CHEMBL1899
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	HSD11B2	11-beta-hydroxysteroid dehydrogenase 2	P80365	CHEMBL3746
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NQO2	Quinone reductase 2	P16083	CHEMBL3959
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	PIK3CA	PI3-kinase p110-alpha subunit	P42336	CHEMBL4005
Enzyme_unclassified	PIK3CB	PI3-kinase p110-beta subunit	P42338	CHEMBL3145
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Nuclear hormone receptor subfamily 2 group B	RXRA	Retinoid X receptor alpha	P19793	CHEMBL2061
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	HTR2C	Serotonin 2c (5-HT2c) receptor	P28335	CHEMBL225
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	HTR5A	Serotonin 5a (5-HT5a) receptor	P47898	CHEMBL3426
Small molecule receptor (family A GPCR)	HTR1F	Serotonin 1f (5-HT1f) receptor	P30939	CHEMBL1805
Small molecule receptor (family A GPCR)	HTR7	Serotonin 7 (5-HT7) receptor	P34969	CHEMBL3155
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	HTR1B	Serotonin 1b (5-HT1b) receptor	P28222	CHEMBL1898
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Small molecule receptor (family A GPCR)	HTR4	Serotonin 4 (5-HT4) receptor	Q13639	CHEMBL1875
Small molecule receptor (family A GPCR)	HTR1D	Serotonin 1d (5-HT1d) receptor	P28221	CHEMBL1983
Small molecule receptor (family A GPCR)	HTR1E	Serotonin 1e (5-HT1e) receptor	P28566	CHEMBL2182
Small molecule receptor (family A GPCR)	HTR2B	Serotonin 2b (5-HT2b) receptor	P41595	CHEMBL1833
Small molecule receptor (family A GPCR)	HTR2A	Serotonin 2a (5-HT2a) receptor	P28223	CHEMBL224
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Small molecule receptor (family A GPCR)	HTR6	Serotonin 6 (5-HT6) receptor	P50406	CHEMBL3371
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	5.454E-11	4.750E-08	HTR1A, HTR1B, HTR5A, HTR7
BP	Unclassified;	GO:0042310; vasoconstriction	1.621E-10	1.217E-07	HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.131E-08	5.865E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C9
MF	Unclassified;	GO:0004872; receptor activity	1.733E-08	7.701E-06	ADORA3, DRD2, DRD3, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR3A, HTR4, HTR5A, HTR6, HTR7, RXRA, TSHR
BP	GO:0009987; cellular process	GO:0002031; G-protein coupled receptor internalization	1.774E-08	7.725E-06	DRD2, DRD3, HTR1B, HTR2B
BP	GO:0032501; multicellular organismal process	GO:0097746; regulation of blood vessel diameter	5.223E-08	2.031E-05	HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	7.277E-08	2.732E-05	CA12, CA14, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	8.245E-08	2.927E-05	CYP1A2, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.585E-07	5.230E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0010513; positive regulation of phosphatidylinositol biosynthetic process	2.057E-07	6.399E-05	HTR2A, HTR2B, HTR2C
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.996E-07	8.698E-05	ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.151E-07	9.028E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	4.106E-07	1.146E-04	CYP1A2, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	4.643E-07	1.248E-04	CYP1A1, CYP1A2, CYP1B1, CYP3A4
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	8.745E-07	2.093E-04	ADORA3, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, TSHR
BP	GO:0009987; cellular process	GO:0014059; regulation of dopamine secretion	1.063E-06	2.488E-04	DRD2, DRD3, HTR1B, HTR2A
MF	GO:0005488; binding	GO:0020037; heme binding	1.498E-06	3.470E-04	CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP3A4, PTGS2
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	1.750E-06	3.773E-04	BCL2, CA7, DRD2, DRD3, HTR2A, HTR2B, HTR2C
BP	GO:0022414; reproductive process	GO:0007566; embryo implantation	3.752E-06	7.495E-04	MMP2, MMP9, PTGS2, RXRA
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	4.463E-06	8.678E-04	CYP1A2, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	4.463E-06	8.678E-04	CYP1A2, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0051378; serotonin binding	2.744E-29	2.987E-25	HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR3A, HTR5A, HTR7
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	1.613E-25	5.854E-22	HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7
MF	GO:0060089; molecular transducer activity	GO:0004993; G-protein coupled serotonin receptor activity	1.613E-25	5.854E-22	HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	5.512E-06	1.035E-03	ALPL, APEX1, BLM, CYP1A1, CYP1B1, ESR1, NFKB1, PTGS2
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.815E-06	1.187E-03	CA12, CA14, CA7, CA9
BP	GO:0023052; signaling	GO:0051967; negative regulation of synaptic transmission, glutamatergic	7.356E-06	1.210E-03	DRD2, HTR1B, HTR2A
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	7.434E-06	1.210E-03	BCL2, CYP1A1, DRD2, HSD11B2, LMNA, MMP2, PTGS2
BP	GO:0051179; localization	GO:0051209; release of sequestered calcium ion into cytosol	7.464E-06	1.210E-03	DRD2, HTR2A, HTR2B, HTR2C
BP	GO:0009987; cellular process	GO:0007208; phospholipase C-activating serotonin receptor signaling pathway	7.671E-06	1.210E-03	HTR2A, HTR2C
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	7.671E-06	1.210E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	7.671E-06	1.210E-03	ALOX12, ALOX15
MF	GO:0005488; binding	GO:0071886; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	7.671E-06	1.210E-03	HTR2A, HTR2C
BP	GO:0065007; biological regulation	GO:0006874; cellular calcium ion homeostasis	1.003E-05	1.475E-03	BCL2, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	1.040E-05	1.520E-03	ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	1.127E-05	1.615E-03	ALOX12, ALOX15, PTGS2
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.252E-05	1.719E-03	BLM, CA12, CA7, CA9, ESR1, L3MBTL1, MMP1, MMP2, MMP9, NQO2, RXRA
BP	GO:0032501; multicellular organismal process	GO:0001503; ossification	1.646E-05	2.121E-03	ALOX15, ALPL, BCL2, MMP2, MMP9
BP	GO:0007610; behavior	GO:0048148; behavioral response to cocaine	2.276E-05	2.689E-03	DRD2, DRD3, HTR2A
BP	GO:0009987; cellular process	GO:0060160; negative regulation of dopamine receptor signaling pathway	2.297E-05	2.689E-03	DRD2, DRD3
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	2.297E-05	2.689E-03	ALOX15, PTGS2
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	2.297E-05	2.689E-03	CYP1A1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	2.297E-05	2.689E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	2.297E-05	2.689E-03	ALOX12, ALOX15
BP	GO:0008283; cell proliferation	GO:1904707; positive regulation of vascular smooth muscle cell proliferation	3.063E-05	3.369E-03	HTR1B, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	3.516E-05	3.790E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0032501; multicellular organismal process	GO:0040014; regulation of multicellular organism growth	3.669E-05	3.936E-03	BCL2, DRD2, DRD3, PIK3CA
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.586E-05	4.801E-03	CYP1A1, CYP1A2
BP	GO:0032501; multicellular organismal process	GO:0014827; intestine smooth muscle contraction	4.586E-05	4.801E-03	HTR1D, HTR2B
BP	GO:0008152; metabolic process	GO:0018958; phenol-containing compound metabolic process	6.675E-05	6.265E-03	BCL2, DRD2, DRD3, HTR1A
BP	GO:0009987; cellular process	GO:1902533; positive regulation of intracellular signal transduction	6.897E-05	6.445E-03	ALOX15, BCL2, CYP1B1, DRD2, HTR2A, HTR2B, HTR2C, HTR6, PIK3CA, PIK3CB, PTGS2
BP	GO:0040011; locomotion	GO:0090325; regulation of locomotion involved in locomotory behavior	7.630E-05	6.865E-03	DRD2, DRD3
BP	GO:0050896; response to stimulus	GO:0071502; cellular response to temperature stimulus	7.630E-05	6.865E-03	HTR1B, HTR2B
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	7.630E-05	6.865E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	7.630E-05	6.865E-03	CYP1A1, CYP3A4
BP	GO:0007610; behavior	GO:0001662; behavioral fear response	7.949E-05	7.094E-03	BCL2, HTR1A, HTR2C
BP	GO:0050896; response to stimulus	GO:0010039; response to iron ion	8.783E-05	7.806E-03	BCL2, CYP1A1, DRD2
BP	GO:0023052; signaling	GO:0032228; regulation of synaptic transmission, GABAergic	9.672E-05	8.425E-03	CA7, DRD2, HTR1B
BP	GO:0065007; biological regulation	GO:0010863; positive regulation of phospholipase C activity	1.062E-04	9.139E-03	ESR1, HTR2A, HTR2B
BP	GO:0050896; response to stimulus	GO:0071417; cellular response to organonitrogen compound	1.097E-04	9.369E-03	APEX1, BLM, HTR1B, MMP2, NFKB1, PTGS2, TSHR
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.142E-04	9.605E-03	CYP1A1, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	5.861E-26	8.322E-24	HTR1E, HTR1F, HTR1D, ALOX15, HTR1A, HTR2B, HTR1B, HTR2C, ALOX12, HTR3A, HTR2A, HTR5A, HTR4, PTGS2, CYP2C9, HTR6, HTR7
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.564E-17	1.110E-15	HTR1E, HTR1F, HTR1D, HTR1A, HTR2B, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, TSHR, HTR6, HTR7, ADORA3, DRD2, DRD3
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.605E-13	7.598E-12	HTR6, HTR1E, PIK3CA, HTR1F, HTR1D, HTR1A, HTR1B, PIK3CB, HTR4, DRD2, NFKB1, TSHR
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.274E-09	8.073E-08	HSD11B1, CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP3A4, PTGS2
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.057E-08	3.003E-07	HSD11B1, HSD11B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.312E-08	1.020E-06	HSD11B1, CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09150 Organismal Systems	09157 Sensory system	hsa04742	Taste transduction	9.365E-08	1.829E-06	HTR1E, HTR1F, HTR1D, HTR1A, HTR1B, HTR3A
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2.532E-07	3.596E-06	PIK3CA, HTR2B, HTR2C, ALOX12, PIK3CB, HTR2A
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	1.159E-07	1.829E-06	RXRA, PIK3CA, BCL2, PIK3CB, PTGS2, NFKB1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.055E-06	1.171E-05	RXRA, PIK3CA, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	5.275E-07	6.810E-06	HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7.725E-06	7.313E-05	PIK3CA, MMP2, BCL2, PIK3CB, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	7.004E-06	7.104E-05	PIK3CA, MMP2, PIK3CB, ESR1, MMP9
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.172E-05	1.040E-04	PIK3CA, PIK3CB, PTGS2, MMP9, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.755E-05	2.539E-04	PIK3CA, LMNA, BCL2, PIK3CB, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.788E-05	1.410E-04	PIK3CA, ADORA3, BCL2, PIK3CB, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.571E-05	1.312E-04	PIK3CA, PIK3CB, PTGS2, TSHR
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	4.590E-05	2.834E-04	PIK3CA, BCL2, PIK3CB, MMP9, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	9.160E-05	5.314E-04	HSD11B1, CYP2C9, FUT7, CYP1A2, ALOX15, CYP1A1, ALPL, ALOX12, PTGS2, PGD, CYP3A4, HSD17B10
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.357E-05	1.762E-04	CYP2C9, ALOX15, ALOX12, PTGS2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.072E-06	1.171E-05	CYP2C9, CYP1A2, ALOX15, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	4.261E-05	2.750E-04	PIK3CA, PIK3CB, ESR1, NFKB1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.100E-07	1.829E-06	CA12, CA7, CA9, CA14
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.844E-05	2.019E-04	CYP2C9, CYP1A2, CYP1A1, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.447E-04	7.609E-04	PIK3CA, BCL2, CYP1B1, PTGS2, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	9.776E-05	5.339E-04	PIK3CA, BCL2, PIK3CB, NFKB1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	2.165E-04	9.609E-04	PIK3CA, MMP2, PIK3CB, ESR1, MMP9
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	9.355E-05	5.314E-04	HTR2B, HTR2C, HTR2A, DRD2
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	2.295E-04	9.875E-04	ACHE, PIK3CA, BCL2, PIK3CB
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.721E-04	8.148E-04	PIK3CA, BCL2, PIK3CB, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	2.900E-04	1.144E-03	PIK3CA, BCL2, PIK3CB, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	2.900E-04	1.144E-03	RXRA, PIK3CA, PIK3CB, ESR1
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	3.092E-04	1.187E-03	PIK3CA, BCL2, PIK3CB, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	2.900E-04	1.144E-03	PIK3CA, MMP2, PIK3CB, MMP9
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	4.569E-04	1.655E-03	RXRA, PIK3CA, PIK3CB, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	7.364E-04	2.377E-03	RXRA, PIK3CA, PIK3CB, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	2.232E-03	6.096E-03	RXRA, PIK3CA, BCL2, PIK3CB, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	2.153E-03	5.995E-03	PIK3CA, BCL2, PIK3CB, NFKB1
09150 Organismal Systems	09155 Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1.587E-04	8.050E-04	HSD11B2, PIK3CA, PIK3CB
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	4.661E-04	1.655E-03	RXRA, PIK3CA, PIK3CB
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.713E-04	8.148E-04	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	5.994E-04	2.027E-03	PIK3CA, PIK3CB, PTGS2
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.844E-04	8.449E-04	MMP1, MMP2, MMP9
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	1.012E-03	2.995E-03	PIK3CA, PIK3CB, NFKB1
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	2.097E-03	5.955E-03	PIK3CA, PIK3CB, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	3.278E-03	8.026E-03	HTR7, PIK3CA, PIK3CB, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	4.911E-04	1.701E-03	PIK3CA, PIK3CB, NFKB1
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	7.549E-04	2.382E-03	PIK3CA, PIK3CB, NFKB1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.012E-03	2.995E-03	PIK3CA, PIK3CB, NFKB1
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	6.287E-04	2.076E-03	PIK3CA, BCL2, PIK3CB
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	2.034E-03	5.893E-03	BCL2, PTGS2, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05146	Amoebiasis	2.501E-03	6.700E-03	PIK3CA, PIK3CB, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	2.795E-03	7.216E-03	PIK3CA, PIK3CB, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	2.950E-03	7.480E-03	PIK3CA, PIK3CB, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	3.334E-04	1.246E-03	CYP1A1, CYP1B1, PTGS2
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	3.192E-03	7.951E-03	PIK3CA, PIK3CB, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	2.795E-03	7.216E-03	PIK3CA, PIK3CB, NFKB1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8.594E-04	2.653E-03	CYP2C9, CYP1A2, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HSD11B1; HTR2C; HTR6;
C00-D49: Neoplasms	Aggressive non-hodgkin's lymphoma	C81, C81-C86, C82-C85, C91-C95	HTR2C;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	DRD2; PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3; PTGS2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	DRD2; PTGS2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	DRD2; HTR2A; HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Advanced stage Parkinson's disease	F02.3, G20	DRD2;
K00-K95: Diseases of the digestive system	Dermal necrosis	K05	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Depressive fatigue	R53.82	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR2A; HTR2B; HTR2C; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HTR6;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HSD11B1; HTR2A; HTR2C;
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	HTR2B;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
H00-H59: Diseases of the eye and adnexa	Ophthalmic disease	H00-H59	DRD2;
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	HTR2B;
NA: NA	Cervical dystonia	NA	HTR1A;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3; DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	DRD2;
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	HTR1D;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
NA: NA	Episode	NA	HTR1A;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
I00-I99: Diseases of the circulatory system	Maintain blood pressure in hypotensive states	I10	DRD2;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1;
NA: NA	Menopausal disorder	NA	ESR1;
NA: NA	Malignant phaeochromocytoma	NA	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE; HTR6;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1; PTGS2;
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Erythropoietic porphyria	E80.0	HTR2A;
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1; HTR2C;
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1;
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1;
J00-J99: Diseases of the respiratory system	Nasal congestion	J34.89	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	DRD2; HTR3A;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1;
J00-J99: Diseases of the respiratory system	Asthma	J45	DRD2; PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PTGS2; MMP1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR7; DRD2; DRD3; HTR2A; HTR2C; HTR6; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR7; DRD2; HTR2C; HTR1A; HTR1B; HTR1D;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	DRD2;
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	HTR2A;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PTGS2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD2; DRD3; HTR6; HTR3A;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	HTR2A; HTR2B; HTR1F; HTR1A; HTR1D;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9; DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	HTR1A;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
NA: NA	Upper abdominal bloating	NA	ACHE;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Idiopathic thrombocytopenic purpura	D69.3	DRD2;
NA: NA	Inflammatory diseases	NA	DRD2;
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	DRD2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychoses	F20-F29	HTR2B;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1; MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B1; HSD11B2; NFKB1; PTGS2;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A;
I00-I99: Diseases of the circulatory system	Hypotension	I95	DRD2;
NA: NA	Joint and muscular pain	NA	PTGS2;
NA: NA	Itching	NA	DRD2;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1;
NA: NA	False perceptions	NA	DRD2;
NA: NA	Vomiting	NA	DRD2; HTR3A;
NA: NA	Sleep initiation and maintenance disorders	NA	HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep maintenance insomnia	F51.0, G47.0	HTR2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	PIK3CA;
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1; BCL2;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	HTR2B; HTR3A;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	HTR2A;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; DRD2; HTR6; PTGS2; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	HTR2A; HTR3A;
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1;
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1;
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1;
C00-D49: Neoplasms	Breast cancer	C50	ESR1; DRD2; NQO2; CA9; BCL2;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9; BCL2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Local anaesthetic	R20.0	HTR3A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PTGS2;
NA: NA	Corneal vascularity	NA	DRD2;
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1;
I00-I99: Diseases of the circulatory system	Coronary heart disease	I25.1	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD2;
NA: NA	Benign prostatic hypertrophy	NA	DRD2;
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; DRD2; HTR1A;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9;
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	PIK3CB;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS2; MMP2;
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HTR7; HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	HTR1A; HTR1D;
NA: NA	Postmenopausal disorder	NA	ESR1;
O00-O9A: Pregnancy, childbirth and the puerperium	Postpartum haemorrhage	O72	DRD2;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
NA: NA	Social phobia	NA	HTR1A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A;
C00-D49: Neoplasms	Solid tumours	C00-D48	PIK3CA; MMP9; PIK3CB; MMP2; CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
NA: NA	Peripheral vasoconstriction	NA	DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1;
I00-I99: Diseases of the circulatory system	Hemorrhoids	I84	HTR2A;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2;
NA: NA	Schizoaffective disorders	NA	DRD2;
NA: NA	Rheumatold arthritis	NA	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PTGS2; MMP1;
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	DRD2; HTR2C; HTR1B; HTR1D;
NA: NA	Peripheral sensory neuropathies	NA	HTR1A;
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1;
C00-D49: Neoplasms	Multiple myeloma	C90	BCL2;
E00-E89: Endocrine, nutritional and metabolic diseases	Carcinoid syndrome	E34.0	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HTR2A;
I00-I99: Diseases of the circulatory system	Cardiotonic	I50	DRD2;
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	DRD2;
NA: NA	Addiction	NA	HTR2A;
I00-I99: Diseases of the circulatory system	Pulmonary hypertension	I27.0, I27.2	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1; DRD3; HTR1A;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	DRD2;
C00-D49: Neoplasms	Cancer	C00-C96	ESR1; PIK3CA; NFKB1; ACHE; ADORA3; MMP9; PTGS2; PIK3CB; NQO2; MMP2; CA9; BCL2;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD2; HTR1A;
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperprolactinemia	E22.1	DRD2;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1;
NA: NA	Primary insomnia	NA	HTR2C;
C00-D49: Neoplasms	Prostate cancer	C61	ESR1; BCL2;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	BCL2;
NA: NA	Malignant essential hypertension	NA	DRD2;
NA: NA	Bulimia nervosa	NA	HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1;
NA: NA	Hyperaemia	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	DRD2;
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	HTR1D;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychosis	F20-F29	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR2A; HTR1A;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD2; DRD3; HTR2C; HTR1A; HTR1B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR2A; HTR2C; HTR1A; HTR1B; HTR1D;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1; HTR2C; HTR6;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
E00-E89: Endocrine, nutritional and metabolic diseases	Acromegaly	E22.0	DRD2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; ADORA3; DRD2; HTR2A;
NA: NA	Gonorrheal vaginitis	NA	ESR1;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1; ACHE; DRD2; HTR2C; PTGS2; HTR1A;
C00-D49: Neoplasms	Pancreatic cancer	C25	PTGS2; MMP2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; HTR6; HTR1A;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Chronic schizophrenics	F20	HTR1B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD3;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;
NA: NA	Schizoaffective disorder	NA	HTR1A;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3; HTR2C;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR2C; HTR1A;
K00-K95: Diseases of the digestive system	Gastrointestinal problems	K30-K31, Q40-Q41	DRD2;
K00-K95: Diseases of the digestive system	Gastroesophageal reflux disease	K21	HTR3A;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2;
NA: NA	Anxiety disorders	NA	HTR1A;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; ACHE; DRD2; HTR2A; HTR2C; HTR6; HTR1A; HTR1B;
C00-D49: Neoplasms	Cutaneous T-cell lymphoma	C84.0, C84.1	RXRA;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	DRD2; PTGS2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases