CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPR55;
Enzyme_unclassified	TERT;
Lysine demethylase	KDM4E;
Transferase	MDM2;
Unclassified	XBP1; MAPT; HTT; RAB9A; NPC1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Small molecule receptor (family A GPCR)	GPR55	G-protein coupled receptor 55	Q9Y2T6	CHEMBL1075322
Transferase	MDM2	p53-binding protein Mdm-2	Q00987	CHEMBL5023
Unclassified	XBP1	X-box-binding protein 1	P17861	CHEMBL1741176
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0031648; protein destabilization	1.558E-06	3.393E-02	HTT, MDM2, XBP1
BP	GO:0009987; cellular process	GO:2001234; negative regulation of apoptotic signaling pathway	4.301E-06	3.608E-02	HTT, MDM2, TERT, XBP1
BP	GO:0009987; cellular process	GO:1990000; amyloid fibril formation	8.240E-06	3.608E-02	MAPT, MDM2
MF	GO:0005488; binding	GO:0042802; identical protein binding	7.325E-06	3.608E-02	HTT, MAPT, MDM2, RAB9A, SMN1, SMN2, TERT

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	3.843E-03	1.038E-01	SMN2, SMN1
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	8.443E-03	1.140E-01	XBP1, TERT
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.233E-02	1.315E-01	MDM2
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	3.518E-02	1.315E-01	MDM2
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	3.837E-02	1.315E-01	MDM2
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	3.943E-02	1.315E-01	MDM2
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	4.789E-02	1.315E-01	MDM2
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.062E-01	1.315E-01	MDM2
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05016	Huntington's disease	1.012E-01	1.315E-01	HTT
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	1.057E-01	1.315E-01	MDM2

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
C00-D49: Neoplasms	Cancer	C00-C96	MDM2;
C00-D49: Neoplasms	Prostate cancer	C61	MDM2;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	MDM2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MDM2;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	MDM2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MDM2;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;

Showing 1 to 8 of 8 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Arnica longifolia

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities