Plant Name: Arnica longifolia
Taxonomic Information:
Plant ID: NPO20876
Plant Latin Name: Arnica longifolia
Taxonomy Genus: Arnica
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
149410
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPR55; | |
| TERT; | |
| KDM4E; | |
| MDM2; | |
| XBP1; MAPT; HTT; RAB9A; NPC1; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Small molecule receptor (family A GPCR) | GPR55 | G-protein coupled receptor 55 | Q9Y2T6 | CHEMBL1075322 |
| Transferase | MDM2 | p53-binding protein Mdm-2 | Q00987 | CHEMBL5023 |
| Unclassified | XBP1 | X-box-binding protein 1 | P17861 | CHEMBL1741176 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0065007; biological regulation | GO:0031648; protein destabilization | 1.558E-06 | 3.393E-02 | HTT, MDM2, XBP1 |
| BP | GO:0009987; cellular process | GO:2001234; negative regulation of apoptotic signaling pathway | 4.301E-06 | 3.608E-02 | HTT, MDM2, TERT, XBP1 |
| BP | GO:0009987; cellular process | GO:1990000; amyloid fibril formation | 8.240E-06 | 3.608E-02 | MAPT, MDM2 |
| MF | GO:0005488; binding | GO:0042802; identical protein binding | 7.325E-06 | 3.608E-02 | HTT, MAPT, MDM2, RAB9A, SMN1, SMN2, TERT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09120 Genetic Information Processing | 09122 Translation | hsa03013 | RNA transport | 3.843E-03 | 1.038E-01 | SMN2, SMN1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 8.443E-03 | 1.140E-01 | XBP1, TERT |
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 2.233E-02 | 1.315E-01 | MDM2 |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 3.518E-02 | 1.315E-01 | MDM2 |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 3.837E-02 | 1.315E-01 | MDM2 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 3.943E-02 | 1.315E-01 | MDM2 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 4.789E-02 | 1.315E-01 | MDM2 |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 1.062E-01 | 1.315E-01 | MDM2 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05016 | Huntington's disease | 1.012E-01 | 1.315E-01 | HTT |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05169 | Epstein-Barr virus infection | 1.057E-01 | 1.315E-01 | MDM2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | MDM2; |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2; |
| C00-D49: Neoplasms | Prostate cancer | C61 | MDM2; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | MDM2; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MDM2; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | MDM2; |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MDM2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
