CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	MAOA;
Enzyme_unclassified	AKR1B10;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409

Showing 1 to 4 of 4 entries

Previous1Next

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0008131; primary amine oxidase activity	1.242E-03	6.289E-01	MAOA
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	1.449E-03	6.713E-01	AKR1B10
MF	GO:0060089; molecular transducer activity	GO:0004887; thyroid hormone receptor activity	1.449E-03	6.713E-01	NR1H4
MF	GO:0005488; binding	GO:0046965; retinoid X receptor binding	3.103E-03	9.255E-01	NR1H4

Showing 1 to 4 of 4 entries

Previous1Next

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00340	Histidine metabolism	4.792E-03	1.793E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00360	Phenylalanine metabolism	3.396E-03	1.793E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00350	Tyrosine metabolism	6.982E-03	1.793E-02	MAOA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	7.181E-03	1.793E-02	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	5.987E-03	1.793E-02	AKR1B10
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	7.977E-03	1.793E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7.977E-03	1.793E-02	MAOA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6.385E-03	1.793E-02	AKR1B10
09100 Metabolism	09105 Amino acid metabolism	hsa00330	Arginine and proline metabolism	9.963E-03	1.793E-02	MAOA
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	9.765E-03	1.793E-02	MAOA

Showing 1 to 10 of 10 entries

Previous1Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOA;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA;

Showing 1 to 10 of 10 entries

Previous1Next

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Jacobaea persoonii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities