CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A;
Peptide receptor (family A GPCR)	NMUR2; TSHR;
Hydrolase	ACHE; GAA;
Potassium channels	KCNH2;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	SCD; POLB;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	SCD	Acyl-CoA desaturase	O00767	CHEMBL5555
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Potassium channels	KCNH2	HERG	Q12809	CHEMBL240
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	1.768E-06	1.069E-02	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	1.768E-06	1.069E-02	ADRA2A, ADRA2C
BP	GO:0065007; biological regulation	GO:0042592; homeostatic process	2.210E-06	1.069E-02	ADRA2A, GAA, KCNH2, MAPK1, NMUR2, NR1H4, POLB
BP	GO:0032501; multicellular organismal process	GO:0006940; regulation of smooth muscle contraction	5.887E-06	1.165E-02	ADRA2A, ADRA2C, NMUR2
BP	GO:0009987; cellular process	GO:0010700; negative regulation of norepinephrine secretion	8.240E-06	1.196E-02	ADRA2A, ADRA2C
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	8.842E-07	1.069E-02	ADRA2A, ADRA2C
MF	GO:0005488; binding	GO:0051379; epinephrine binding	8.240E-06	1.196E-02	ADRA2A, ADRA2C
MF	Unclassified;	GO:0004871; signal transducer activity	1.029E-05	1.400E-02	ADRA2A, ADRA2C, KCNH2, MAPK1, NMUR2, NR1H4, TSHR
MF	GO:0060089; molecular transducer activity	GO:0038023; signaling receptor activity	4.389E-05	3.491E-02	ADRA2A, ADRA2C, KCNH2, NMUR2, NR1H4, TSHR
MF	GO:0005488; binding	GO:0031690; adrenergic receptor binding	4.489E-05	3.491E-02	ADRA2A, ADRA2C

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.101E-05	1.123E-03	NMUR2, ADRA2C, ADRA2A, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	8.982E-05	4.581E-03	MAPK1, ADRA2C, ADRA2A
09130 Environmental Information Processing	09132 Signal transduction	hsa04350	TGF-beta signaling pathway	4.525E-02	9.117E-02	MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	1.625E-03	5.525E-02	ACHE, MAPK1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	3.943E-02	9.117E-02	MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	3.837E-02	9.117E-02	TSHR
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.837E-02	9.117E-02	NR1H4
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.731E-02	9.117E-02	SCD
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	3.943E-02	9.117E-02	MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	3.943E-02	9.117E-02	MAPK1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	SCD;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	SCD;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	SCD;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	SCD;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Coffea bengalensis

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities