CMAUP Plant Collective Molecular Activities

Plant Name: Colchicum macedonicum

Taxonomic Information:

Plant ID: NPO20696
Plant Latin Name: Colchicum macedonicum
Taxonomy Genus: Colchicum
Taxonomy Family: Colchicaceae

Plant External Links:

NCBI TaxonomyDB: 225786
Plant-of-the-World-Online: 533334-1

Used in Medicines:

Unknown.

Geographical Distribution:

Albania

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	CDA; TK1; AKR1B1; ALOX15; AKR1B10;
Transient receptor potential channel	TRPA1;
Lyase	CA12; CA9;
Oxidoreductase	PTGS1; XDH;
Cysteine protease	CASP1; CASP7;
Transcription Factor	HIF1A;
SLC superfamily of solute carriers	SLC28A1; SLC28A3;
Unclassified	LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP3A4; CYP1A2; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Enzyme_unclassified	TK1	Thymidine kinase, cytosolic	P04183	CHEMBL2883
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
SLC superfamily of solute carriers	SLC28A1	Sodium/nucleoside cotransporter 1	O00337	CHEMBL5551
SLC superfamily of solute carriers	SLC28A3	Solute carrier family 28 member 3	Q9HAS3	CHEMBL5707
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.008E-15	1.961E-10	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	5.143E-10	2.240E-06	ALOX15, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, XDH
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	7.512E-10	2.337E-06	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	7.512E-10	2.337E-06	CYP1A2, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.779E-09	3.875E-06	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	3.442E-09	5.765E-06	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, PTGS1
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	5.894E-09	7.690E-06	CYP1A2, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	6.926E-09	8.378E-06	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, PTGS1
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.057E-08	1.129E-05	AKR1B1, AKR1B10, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	6.917E-08	5.793E-05	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.760E-07	1.369E-04	CYP1A2, CYP2C19, CYP2C9
MF	GO:0005215; transporter activity	GO:0015389; pyrimidine- and adenine-specific:sodium symporter activity	1.356E-06	8.438E-04	SLC28A1, SLC28A3
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.934E-06	1.138E-03	CYP1A2, CYP2C19, CYP2C9
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	2.512E-06	1.436E-03	CASP1, CASP7, MAPT, XDH
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.571E-06	1.436E-03	CYP1A2, CYP2D6, CYP3A4
BP	GO:0051179; localization	GO:1904823; purine nucleobase transmembrane transport	4.066E-06	1.967E-03	SLC28A1, SLC28A3
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	4.066E-06	1.967E-03	CYP2D6, CYP3A4
BP	GO:0051179; localization	GO:0015855; pyrimidine nucleobase transport	4.066E-06	1.967E-03	SLC28A1, SLC28A3
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.892E-05	8.239E-03	AKR1B1, AKR1B10, XDH
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	6.722E-05	2.121E-02	AKR1B1, HIF1A, MAPT
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	6.854E-05	2.132E-02	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, PTGS1, SLC28A3

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.472E-10	7.510E-09	CYP2C9, CYP1A2, ALOX15, CYP3A4, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.341E-08	5.680E-07	CYP2C9, CDA, AKR1B10, CYP1A2, ALOX15, AKR1B1, TK1, CYP2C19, CYP3A4, XDH, PTGS1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.352E-08	3.448E-07	CYP2C9, CYP2D6, CYP1A2, CYP3A4, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.563E-07	1.993E-06	CYP2C9, CYP2D6, ALOX15, CYP2C19, PTGS1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2.100E-07	2.142E-06	CDA, TK1, CYP3A4, XDH
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	7.092E-07	6.028E-06	CYP2C9, ALOX15, CYP2C19, PTGS1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.372E-06	9.997E-06	CYP2C9, CYP2D6, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.190E-06	1.396E-05	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5.539E-05	2.825E-04	CYP2C9, CYP1A2, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.876E-03	5.893E-03	TSHR, PTGS1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.810E-03	5.893E-03	CASP7, CASP1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	2.080E-03	5.893E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	7.783E-04	2.835E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	5.396E-04	2.293E-03	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.011E-03	5.893E-03	CYP1A2, CYP3A4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6.144E-04	2.410E-03	AKR1B10, AKR1B1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	3.336E-03	8.954E-03	CASP7, CASP1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.703E-04	7.893E-04	CA12, CA9
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.262E-05	7.154E-05	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	TK1; CDA; CA9;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TK1;
C00-D49: Neoplasms	Prostate cancer	C61	TK1;
A00-B99: Certain infectious and parasitic diseases	Adult varicella zoster virus infection	B02	TK1;
C00-D49: Neoplasms	Pancreatic cancer	C25	TK1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
S00-T88: Injury, poisoning and certain other consequences of external causes	Graft-versus-host disease	T86.0	TK1;
C00-D49: Neoplasms	Brain cancer	C71, D33	TK1;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	TK1; CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases