Plant ID: NPO20647
Plant Latin Name: Eugenia myrcianthes
Taxonomy Genus: Eugenia
Taxonomy Family: Myrtaceae
NCBI TaxonomyDB:
260132
Plant-of-the-World-Online:
n.a.
GPBAR1; | |
NR1H4; | |
MAOA; | |
AKR1B10; |
Cytochrome P450 Enzymes: |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0003824; catalytic activity | GO:0008131; primary amine oxidase activity | 1.242E-03 | 6.289E-01 | MAOA |
MF | GO:0003824; catalytic activity | GO:0001758; retinal dehydrogenase activity | 1.449E-03 | 6.713E-01 | AKR1B10 |
MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 1.449E-03 | 6.713E-01 | NR1H4 |
MF | GO:0005488; binding | GO:0046965; retinoid X receptor binding | 3.103E-03 | 9.255E-01 | NR1H4 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09105 Amino acid metabolism | hsa00340 | Histidine metabolism | 4.792E-03 | 1.793E-02 | MAOA |
09100 Metabolism | 09105 Amino acid metabolism | hsa00360 | Phenylalanine metabolism | 3.396E-03 | 1.793E-02 | MAOA |
09100 Metabolism | 09105 Amino acid metabolism | hsa00350 | Tyrosine metabolism | 6.982E-03 | 1.793E-02 | MAOA |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 7.181E-03 | 1.793E-02 | AKR1B10 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 5.987E-03 | 1.793E-02 | AKR1B10 |
09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 7.977E-03 | 1.793E-02 | MAOA |
09100 Metabolism | 09105 Amino acid metabolism | hsa00260 | Glycine, serine and threonine metabolism | 7.977E-03 | 1.793E-02 | MAOA |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 6.385E-03 | 1.793E-02 | AKR1B10 |
09160 Human Diseases | 09164 Substance dependence | hsa05030 | Cocaine addiction | 9.765E-03 | 1.793E-02 | MAOA |
09100 Metabolism | 09105 Amino acid metabolism | hsa00330 | Arginine and proline metabolism | 9.963E-03 | 1.793E-02 | MAOA |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | MAOA; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | MAOA; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | MAOA; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | MAOA; |
G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAOA; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | MAOA; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | MAOA; |
G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | MAOA; |
G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | MAOA; |
L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | MAOA; |