CMAUP Plant Collective Molecular Activities

Plant Name: Menispermum dauricum

Taxonomic Information:

Plant ID: NPO20526
Plant Latin Name: Menispermum dauricum
Taxonomy Genus: Menispermum
Taxonomy Family: Menispermaceae

Plant External Links:

NCBI TaxonomyDB: 49683
Plant-of-the-World-Online: 581056-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Japan; China; Russia; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD3; DRD4; DRD1; DRD2; DRD5;
Enzyme_unclassified	TDP1; HSD17B1; POLB;
Hydrolase	GAA;
Lyase	CA7; CA4; CA12;
Unclassified	F3;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP3A4; CYP19A1; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	DRD4	Dopamine D4 receptor	P21917	CHEMBL219
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Small molecule receptor (family A GPCR)	DRD5	Dopamine D5 receptor	P21918	CHEMBL1850
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0035240; dopamine binding	3.541E-13	3.855E-09	DRD1, DRD2, DRD3, DRD4, DRD5
BP	GO:0050896; response to stimulus	GO:0001975; response to amphetamine	1.798E-11	9.787E-08	DRD1, DRD2, DRD3, DRD4, DRD5
BP	GO:0007610; behavior	GO:0048148; behavioral response to cocaine	1.972E-09	3.302E-06	DRD1, DRD2, DRD3, DRD4
MF	GO:0060089; molecular transducer activity	GO:0001591; dopamine neurotransmitter receptor activity, coupled via Gi/Go	3.162E-08	3.159E-05	DRD2, DRD3, DRD4
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.982E-08	4.652E-05	CYP19A1, CYP1B1, CYP2C19, CYP3A4
BP	GO:0009987; cellular process	GO:0007191; adenylate cyclase-activating dopamine receptor signaling pathway	6.769E-08	4.913E-05	DRD1, DRD3, DRD5
BP	GO:0009987; cellular process	GO:0007195; adenylate cyclase-inhibiting dopamine receptor signaling pathway	6.769E-08	4.913E-05	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0034776; response to histamine	9.302E-08	6.138E-05	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0060134; prepulse inhibition	1.611E-07	8.992E-05	DRD1, DRD2, DRD3
BP	GO:0009987; cellular process	GO:0060158; phospholipase C-activating dopamine receptor signaling pathway	1.611E-07	8.992E-05	DRD1, DRD2, DRD5
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.559E-07	1.267E-04	CA12, CA4, CA7
BP	GO:0007610; behavior	GO:0046960; sensitization	7.290E-07	2.940E-04	DRD1, DRD5
BP	GO:0051179; localization	GO:0050482; arachidonic acid secretion	9.919E-07	3.576E-04	DRD2, DRD3, DRD4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	9.919E-07	3.576E-04	CYP19A1, CYP1B1, CYP3A4
BP	GO:0009987; cellular process	GO:0060160; negative regulation of dopamine receptor signaling pathway	2.186E-06	6.103E-04	DRD2, DRD3
BP	GO:0023052; signaling	GO:0051586; positive regulation of dopamine uptake involved in synaptic transmission	2.186E-06	6.103E-04	DRD2, DRD4
BP	GO:0065007; biological regulation	GO:0007194; negative regulation of adenylate cyclase activity	2.764E-06	7.166E-04	DRD2, DRD3, DRD4
CC	GO:0043226; organelle	GO:0097730; non-motile cilium	2.764E-06	7.166E-04	DRD1, DRD2, DRD5
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	3.332E-06	8.338E-04	CYP19A1, CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.971E-06	9.715E-04	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0020037; heme binding	4.095E-06	9.908E-04	CYP19A1, CYP1B1, CYP2C19, CYP3A4
MF	GO:0060089; molecular transducer activity	GO:0001588; dopamine neurotransmitter receptor activity, coupled via Gs	4.370E-06	1.034E-03	DRD1, DRD5
BP	GO:0065007; biological regulation	GO:0045776; negative regulation of blood pressure	6.364E-06	1.386E-03	DRD2, DRD3, DRD5
BP	Unclassified;	GO:0021853; cerebral cortex GABAergic interneuron migration	7.279E-06	1.506E-03	DRD1, DRD2
BP	GO:0040011; locomotion	GO:0090325; regulation of locomotion involved in locomotory behavior	7.279E-06	1.506E-03	DRD2, DRD3
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.333E-06	1.506E-03	CA12, CA4, CA7
BP	GO:0007610; behavior	GO:0008542; visual learning	9.556E-06	1.875E-03	DRD1, DRD2, DRD3
MF	GO:0005488; binding	GO:0005506; iron ion binding	9.921E-06	1.929E-03	CYP19A1, CYP1B1, CYP2C19, CYP3A4
BP	Unclassified;	GO:0032415; regulation of sodium:proton antiporter activity	1.091E-05	1.948E-03	DRD3, DRD4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.091E-05	1.948E-03	CYP2C19, CYP3A4
BP	GO:0065007; biological regulation	GO:0006874; cellular calcium ion homeostasis	1.480E-05	2.538E-03	DRD1, DRD2, DRD3, DRD4, DRD5
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	2.785E-05	4.271E-03	CA7, DRD1, DRD2, DRD3
BP	GO:0032501; multicellular organismal process	GO:0030432; peristalsis	3.267E-05	4.840E-03	DRD1, DRD2
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.267E-05	4.840E-03	CYP1B1, CYP2C19
BP	GO:0009987; cellular process	GO:0002031; G-protein coupled receptor internalization	3.991E-05	5.607E-03	DRD2, DRD3
BP	GO:0032502; developmental process	GO:0021756; striatum development	3.991E-05	5.607E-03	DRD1, DRD2
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	4.787E-05	6.395E-03	CYP2C19, CYP3A4
BP	GO:0007610; behavior	GO:0007625; grooming behavior	4.787E-05	6.395E-03	DRD1, DRD2
BP	GO:0051179; localization	GO:0002028; regulation of sodium ion transport	4.981E-05	6.494E-03	DRD2, DRD3, DRD4
CC	GO:0044422; organelle part	GO:0060170; ciliary membrane	4.981E-05	6.494E-03	DRD1, DRD2, DRD5
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	5.654E-05	7.285E-03	CYP19A1, HSD17B1
BP	GO:0032501; multicellular organismal process	GO:0035815; positive regulation of renal sodium excretion	5.654E-05	7.285E-03	DRD2, DRD3
BP	GO:0007610; behavior	GO:0048149; behavioral response to ethanol	6.593E-05	8.299E-03	DRD2, DRD4
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	7.900E-05	9.583E-03	CYP19A1, CYP1B1, CYP2C19, CYP3A4, GAA, HSD17B1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	6.005E-08	2.102E-06	DRD1, DRD2, DRD3, DRD4, DRD5
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.473E-07	2.578E-06	HSD17B1, CYP1B1, CYP3A4, CYP19A1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.654E-06	2.322E-05	DRD1, DRD2, DRD3, DRD4, DRD5
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	9.754E-06	6.828E-05	HSD17B1, CYP1B1, CYP19A1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.443E-07	4.017E-06	CA12, CA4, CA7
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.334E-05	2.528E-04	CYP1B1, CYP3A4, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	5.953E-04	2.604E-03	DRD1, DRD2, DRD5
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.724E-04	1.362E-03	CYP3A4, CYP2C19
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	7.811E-04	3.038E-03	DRD1, DRD2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.543E-03	5.400E-03	CYP3A4, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.990E-03	8.051E-03	GAA, HSD17B1, CYP2C19, CYP3A4, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.725E-03	5.488E-03	CYP1B1, CYP3A4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	2.494E-03	7.273E-03	DRD1, DRD2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3;
C00-D49: Neoplasms	Solid tumours	C00-D48	DRD5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1; DRD3;
C00-D49: Neoplasms	Pancreatic cancer	C25	F3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD5; DRD1; DRD3;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1; DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases