CMAUP Plant Collective Molecular Activities

Plant Name: Codium fragile

Taxonomic Information:

Plant ID: NPO20513
Plant Latin Name: Codium fragile
Taxonomy Genus: Codium
Taxonomy Family: Codiaceae

Plant External Links:

NCBI TaxonomyDB: 3133
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Protein Kinase	PRKCA;
Enzyme_unclassified	ALOX15; ALDH1A1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	7.630E-05	5.933E-01	ALOX15, CYP2A6
BP	GO:0008152; metabolic process	GO:0035408; histone H3-T6 phosphorylation	5.177E-04	5.933E-01	PRKCA
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	5.177E-04	5.933E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0016491; oxidoreductase activity	5.077E-04	5.933E-01	ALDH1A1, ALOX15, CYP2A6
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	5.177E-04	5.933E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	5.177E-04	5.933E-01	CYP2A6
MF	GO:0003824; catalytic activity	GO:0035403; histone kinase activity (H3-T6 specific)	5.177E-04	5.933E-01	PRKCA
MF	GO:0005488; binding	GO:0005506; iron ion binding	6.708E-04	6.502E-01	ALOX15, CYP2A6
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	7.764E-04	6.502E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	7.764E-04	6.502E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	7.764E-04	6.502E-01	ALOX15
CC	GO:0044464; cell part	GO:0031234; extrinsic component of cytoplasmic side of plasma membrane	1.850E-02	1.000E+00	ALOX15

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.034E-04	7.028E-03	CYP2A6, ALDH1A1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.074E-04	1.045E-02	ALOX15, PRKCA
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.158E-03	3.668E-02	CYP2A6, ALOX15, ALDH1A1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.250E-03	2.832E-02	CYP2A6
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	1.615E-02	3.939E-02	PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	1.516E-02	3.939E-02	PRKCA
09160 Human Diseases	09167 Infectious diseases	hsa05130	Pathogenic Escherichia coli infection	1.368E-02	3.939E-02	PRKCA
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.541E-02	3.939E-02	ALOX15
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	2.156E-02	3.939E-02	PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	2.500E-02	3.939E-02	PRKCA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases