CMAUP Plant Collective Molecular Activities

Plant Name: Elaeagnus orientalis

Taxonomic Information:

Plant ID: NPO20470
Plant Latin Name: Elaeagnus orientalis
Taxonomy Genus: Elaeagnus
Taxonomy Family: Elaeagnaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Unknown.

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; CDC25B;
Enzyme_unclassified	PLA2G1B; ALDH1A1; AKR1B10; POLB;
Protein Kinase	CDK8; PRKCA; CDK9;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	HIF1A;
Unclassified	NPC1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	CDK8	Cell division protein kinase 8	P49336	CHEMBL5719
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Protein Kinase	CDK9	Cyclin-dependent kinase 9	P50750	CHEMBL3116
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.282E-13	2.484E-09	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.974E-12	2.602E-08	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.546E-11	5.611E-08	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.829E-11	5.688E-08	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	5.080E-10	1.383E-06	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	3.764E-09	5.854E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.427E-09	6.024E-06	CYP1A2, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	9.018E-09	1.034E-05	CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.440E-08	1.363E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	2.421E-07	1.647E-04	CYP1A2, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.934E-06	9.794E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0001523; retinoid metabolic process	2.482E-06	1.186E-03	AKR1B10, ALDH1A1, CYP1A1, CYP1B1
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	3.375E-06	1.441E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	3.375E-06	1.441E-03	CYP1A1, CYP3A4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	3.375E-06	1.441E-03	GPBAR1, NR1H4
MF	GO:0005488; binding	GO:0019899; enzyme binding	4.562E-06	1.910E-03	CDC25B, CDK9, CYP1A1, CYP1A2, CYP2C19, CYP3A4, HIF1A, POLB, PRKCA, PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	6.746E-06	2.623E-03	PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	6.746E-06	2.623E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0016042; lipid catabolic process	8.711E-06	3.270E-03	AKR1B10, CYP1A2, CYP1B1, CYP3A4, PLA2G1B
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	1.124E-05	4.077E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.684E-05	5.915E-03	CYP1A1, CYP3A4
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	1.976E-05	6.829E-03	NR1H4, PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	2.356E-05	7.894E-03	CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	2.356E-05	7.894E-03	AKR1B10, ALDH1A1
BP	GO:0009987; cellular process	GO:0001959; regulation of cytokine-mediated signaling pathway	2.876E-05	9.346E-03	HIF1A, NR1H4, PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	3.140E-05	9.767E-03	CYP1A1, CYP1A2
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	3.535E-05	1.054E-02	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4, RAB9A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.923E-11	8.387E-09	CYP2C9, PLA2G1B, CYP1A2, CYP3A4, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.037E-10	9.574E-09	CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6.059E-09	1.898E-07	CYP2C9, CYP1A2, ALDH1A1, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.096E-08	2.575E-07	CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.427E-07	1.164E-05	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.673E-07	6.904E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.086E-05	2.451E-04	CYP2C9, AKR1B10, PLA2G1B, CYP1A2, ALDH1A1, CYP1A1, CYP2C19, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	9.614E-06	1.291E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.626E-05	3.787E-04	CYP2C9, PLA2G1B, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.113E-04	1.986E-03	CYP2C9, PRKCA, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A;
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; CDC25B;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases