CMAUP Plant Collective Molecular Activities

Plant Name: Glaucium flavum

Taxonomic Information:

Plant ID: NPO20441
Plant Latin Name: Glaucium flavum
Taxonomy Genus: Glaucium
Taxonomy Family: Papaveraceae

Plant External Links:

NCBI TaxonomyDB: 56853
Plant-of-the-World-Online: 673167-1

Used in Medicines:

Country/Region:

China; Bulgaria

Traditional Medicine System:

TCM

Medicinal Functions:

Poultice

Geographical Distribution:

Turkey; Italy; France; Ireland; Argentina; Norway; Algeria; China; Belgium; Germany; Spain; Netherlands; Libya; Denmark; Poland; United States; Morocco; Switzerland; New Zealand; Russia; Bulgaria; Romania; Albania; Tunisia; United Kingdom; Greece; Cyprus

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR7; HTR2A; HTR1A;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	BLM; SENP6; SENP7; SENP8;
Nuclear hormone receptor subfamily 1 group A	THRB;
Cysteine protease	CASP3;
Unclassified	RAD52;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19; CYP2D6; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP3	Caspase-3	P42574	CHEMBL2334
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	SENP6	Sentrin-specific protease 6	Q9GZR1	CHEMBL1741215
Enzyme_unclassified	SENP7	Sentrin-specific protease 7	Q9BQF6	CHEMBL1741213
Enzyme_unclassified	SENP8	Sentrin-specific protease 8	Q96LD8	CHEMBL1741207
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	HTR7	Serotonin 7 (5-HT7) receptor	P34969	CHEMBL3155
Small molecule receptor (family A GPCR)	HTR2A	Serotonin 2a (5-HT2a) receptor	P28223	CHEMBL224
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Unclassified	RAD52	DNA repair protein RAD52 homolog	P43351	CHEMBL2362978

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.528E-12	7.682E-08	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.077E-08	1.172E-04	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.442E-08	2.499E-04	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	8.300E-08	2.582E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	8.300E-08	2.582E-04	CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0051378; serotonin binding	6.228E-08	2.582E-04	HTR1A, HTR2A, HTR7
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	7.593E-07	1.378E-03	HTR1A, HTR2A, HTR7
MF	GO:0060089; molecular transducer activity	GO:0004993; G-protein coupled serotonin receptor activity	7.593E-07	1.378E-03	HTR1A, HTR2A, HTR7
BP	Unclassified;	GO:0042310; vasoconstriction	1.368E-06	2.033E-03	HTR1A, HTR2A, HTR7
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.494E-06	2.033E-03	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.688E-06	2.162E-03	CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	2.373E-06	2.720E-03	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	3.374E-06	2.966E-03	HTR1A, HTR7
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.374E-06	2.966E-03	CYP2C9, CYP3A4
BP	GO:0009987; cellular process	GO:0007188; adenylate cyclase-modulating G-protein coupled receptor signaling pathway	5.213E-06	4.205E-03	HTR1A, HTR7, SENP7, TSHR
MF	GO:0005488; binding	GO:0005506; iron ion binding	5.764E-06	4.483E-03	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0016926; protein desumoylation	1.179E-05	7.465E-03	SENP6, SENP8
MF	GO:0003824; catalytic activity	GO:0008234; cysteine-type peptidase activity	1.338E-05	8.094E-03	CASP3, SENP6, SENP7, SENP8

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	8.857E-13	4.340E-11	CYP2C9, HTR7, CYP2D6, CASP3, HTR1A, HTR2A, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.721E-07	4.216E-06	CYP2C9, CYP2D6, CYP3A4, CYP2C19
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.318E-06	1.614E-05	HTR7, THRB, HTR1A, HTR2A, TSHR
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.233E-06	1.614E-05	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.057E-05	2.016E-04	CYP2C9, CYP2D6, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.917E-05	2.382E-04	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.673E-04	5.786E-03	CYP2C9, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.063E-03	5.786E-03	CYP2C9, CYP3A4
09120 Genetic Information Processing	09124 Replication and repair	hsa03440	Homologous recombination	2.107E-04	1.475E-03	RAD52, BLM
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	7.831E-03	3.837E-02	HTR7, HTR2A

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A;
I00-I99: Diseases of the circulatory system	Hemorrhoids	I84	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR7; HTR2A; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A;
NA: NA	Addiction	NA	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR2A; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR2A; HTR1A;
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	HTR2A;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	HTR1A;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	HTR1A;
NA: NA	Cervical dystonia	NA	HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR2A; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep maintenance insomnia	F51.0, G47.0	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HTR7; HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Erythropoietic porphyria	E80.0	HTR2A;
NA: NA	Episode	NA	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR7; HTR1A;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
NA: NA	Social phobia	NA	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR2A; HTR1A;
NA: NA	Anxiety disorders	NA	HTR1A;
NA: NA	Peripheral sensory neuropathies	NA	HTR1A;
NA: NA	Schizoaffective disorder	NA	HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR1A;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	HTR1A;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	HTR2A; HTR1A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HTR2A;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	HTR1A;
C00-D49: Neoplasms	Cancer	C00-C96	CASP3;
NA: NA	Bulimia nervosa	NA	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	HTR1A;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HTR1A;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	HTR2A;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	HTR2A;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases