CMAUP Plant Collective Molecular Activities

Plant Name: Chrysanthemum x morifolium

Taxonomic Information:

Plant ID: NPO20440
Plant Latin Name: Chrysanthemum x morifolium
Taxonomy Genus: Chrysanthemum
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 41568
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Thailand

Traditional Medicine System:

Kampo

Geographical Distribution:

Thailand

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Hydrolase	ACHE;
Protein Kinase	AURKA; MET; AXL; FLT3; CDK1; MAPK1; PIM1; KDR; CDK8; IGF1R; AURKB; CSNK2A1;
Lyase	CA2; CA12; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Plant homeodomain	PHF8;
Oxidoreductase	TYR;
Enzyme_unclassified	ALOX12; AKR1B1; HSD17B2; HSD17B10; ALOX15; AKR1B10; NOX4; HSD17B1; POLB;
Metallo protease	MMP12; MMP9; MMP1; MMP2;
Transcription Factor	HIF1A; NFKB1; AHR;
Unclassified	LMNA; APP; FABP4; THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C19; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Plant homeodomain	PHF8	Histone lysine demethylase PHF8	Q9UPP1	CHEMBL1938212
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	CDK8	Cell division protein kinase 8	P49336	CHEMBL5719
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.509E-10	3.330E-07	CA12, CA14, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.467E-09	1.389E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, NOX4
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	2.758E-09	2.071E-06	AKR1B1, ALOX12, CDK1, CSNK2A1, FLT3, HIF1A, IGF1R, KDR, MAPK1, MMP12, MMP2, MMP9, PIM1, THPO, TSHR
MF	GO:0005488; binding	GO:0005506; iron ion binding	6.284E-09	3.601E-06	ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PHF8
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	7.588E-09	4.131E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	8.586E-08	3.528E-05	CA12, CA14, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.119E-07	7.323E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.123E-07	9.895E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	5.959E-07	1.545E-04	AURKA, AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1
MF	GO:0005488; binding	GO:0020037; heme binding	8.333E-07	1.994E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, NOX4
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	1.247E-06	2.771E-04	AHR, CSNK2A1, HIF1A, KDR
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	1.374E-06	2.934E-04	AURKA, AXL, CDK1, CSNK2A1, FLT3
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.028E-06	3.839E-04	CA12, CA2, CA4, CA7
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	2.542E-06	4.624E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	4.310E-06	7.332E-04	CYP19A1, HSD17B1, HSD17B2
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.617E-06	7.556E-04	CA12, CA2, CA4, CA7, ESR2, MMP1, MMP12, MMP2, MMP9, NR1H4, PHF8
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	6.304E-06	9.533E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	6.304E-06	9.533E-04	ALOX12, ALOX15
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	7.122E-06	1.034E-03	HIF1A, MMP1, MMP12, MMP2, MMP9
MF	GO:0003824; catalytic activity	GO:0008353; RNA polymerase II carboxy-terminal domain kinase activity	8.394E-06	1.195E-03	CDK1, CDK8, MAPK1
CC	GO:0043226; organelle	GO:0005876; spindle microtubule	9.766E-06	1.367E-03	AURKA, AURKB, CDK1, POLB
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	1.715E-05	2.209E-03	AKR1B1, AXL, CDK1, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.888E-05	2.377E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	1.888E-05	2.377E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	1.888E-05	2.377E-03	ALOX12, ALOX15
BP	GO:0009987; cellular process	GO:0010638; positive regulation of organelle organization	2.113E-05	2.645E-03	ALOX15, AURKA, AURKB, HIF1A, KDR, MAPK1, MET, MMP9, NOX4
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	2.208E-05	2.747E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.622E-05	3.119E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	2.746E-05	3.250E-03	APP, CYP1A1, CYP1B1, FLT3, MAPK1, NFKB1, NOX4
BP	GO:0009987; cellular process	GO:0071345; cellular response to cytokine stimulus	2.952E-05	3.475E-03	ALOX15, AXL, FABP4, FLT3, HIF1A, MAPK1, NFKB1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.770E-05	4.254E-03	CYP1A1, CYP1A2
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	4.774E-05	5.277E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0065007; biological regulation	GO:0051090; regulation of DNA binding transcription factor activity	5.190E-05	5.657E-03	APP, CYP1B1, ESR2, MAPK1, NFKB1, NR1H4, PIM1
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	6.274E-05	6.664E-03	ALOX12, ALOX15
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	6.274E-05	6.664E-03	AURKA, AURKB
BP	GO:0009987; cellular process	GO:0071276; cellular response to cadmium ion	6.559E-05	6.900E-03	CYP1A2, MAPK1, MMP9
CC	GO:0043226; organelle	GO:0051233; spindle midzone	6.559E-05	6.900E-03	APP, AURKA, AURKB
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	8.686E-05	8.797E-03	CYP19A1, CYP1A1, CYP2C19
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	8.857E-05	8.929E-03	ACHE, ALOX15, AURKA, CDK1, CYP1A1
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.395E-05	9.257E-03	CYP1A2, CYP2C19
MF	GO:0003824; catalytic activity	GO:0035174; histone serine kinase activity	9.395E-05	9.257E-03	AURKA, AURKB

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.307E-09	1.765E-07	HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.331E-10	6.626E-08	CA12, CA2, CA4, CA7, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.789E-09	2.953E-07	HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	4.450E-07	1.702E-05	FLT3, MMP1, MMP2, MAPK1, HIF1A, MET, MMP9, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	5.991E-07	1.833E-05	MMP2, KDR, MAPK1, HIF1A, MMP9, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	3.012E-06	7.680E-05	MMP1, MMP2, MAPK1, MMP9
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	7.887E-06	1.724E-04	APP, ALOX15, MAPK1, ALOX12, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.141E-05	2.183E-04	FLT3, PIM1, MAPK1, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.284E-05	4.568E-04	AKR1B10, HSD17B1, HSD17B2, CYP1A2, ALOX15, CYP1A1, AKR1B1, ALOX12, CYP2C19, TYR, CYP19A1, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.175E-05	3.698E-04	FLT3, MAPK1, MET, HIF1A
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	3.225E-05	4.568E-04	CSNK2A1, MAPK1, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	8.336E-05	8.502E-04	PIM1, CYP1B1, MAPK1, MMP9, MET, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.090E-04	9.811E-04	MMP2, PIM1, MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.009E-04	9.646E-04	MMP2, MAPK1, MMP9, ESR2
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	7.728E-05	8.445E-04	FLT3, MMP9, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.832E-05	5.687E-04	CYP1A2, CYP1A1, CYP1B1, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	2.288E-04	1.698E-03	KDR, MAPK1, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.176E-04	9.998E-04	MAPK1, HIF1A, NFKB1, IGF1R
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	2.330E-04	1.698E-03	CDK1, MAPK1, AURKA, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	4.828E-05	5.687E-04	CYP1A2, ALOX15, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.442E-03	7.610E-03	KDR, MAPK1, MET, NFKB1, IGF1R
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.281E-04	1.032E-03	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	4.722E-04	3.284E-03	ALOX15, ALOX12, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	7.026E-04	4.479E-03	MAPK1, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	5.674E-04	3.774E-03	MAPK1, MET, HIF1A
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	7.319E-04	4.479E-03	MAPK1, NFKB1, ESR2
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.354E-03	7.610E-03	MAPK1, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.583E-03	7.815E-03	POLB, CDK1, MAPK1, NFKB1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	1.500E-03	7.651E-03	KDR, MAPK1, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.760E-03	8.276E-03	KDR, MAPK1, MET, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.619E-04	4.484E-03	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1.785E-03	8.276E-03	CDK1, MAPK1, IGF1R
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.440E-03	7.610E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	CLL	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; AURKA; IGF1R; KDR; CSNK2A1; NFKB1; FLT3; ACHE; HIF1A; MMP9; MAPK1; MMP2; APP;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE; APP;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; CYP19A1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1; APP;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
NA: NA	Upper abdominal bloating	NA	ACHE;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
NA: NA	HIV infections	NA	AHR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	AURKA;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1; MMP1; TYR;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKA; AURKB; IGF1R; KDR; FLT3; HIF1A; MMP9; MAPK1; MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; MMP2;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; APP;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR; APP;
NA: NA	Geographic retinal atrophy	NA	APP;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; AKR1B1;
NA: NA	GIST	NA	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; AKR1B1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET; AURKA;
C00-D49: Neoplasms	Haematological malignancies	C81-C86	AURKA;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKA; AURKB; FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases