CMAUP Plant Collective Molecular Activities

Plant Name: Ocimum basilicum

Taxonomic Information:

Plant ID: NPO20414
Plant Latin Name: Ocimum basilicum
Taxonomy Genus: Ocimum
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 39350
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Brazil; Israel; Italy; Mexico; Lebanon; Tanzania; Indonesia; India; Rwanda; Jordan; China; Thailand; Switzerland; Kenya; Argentina; Philippines; Nigeria

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM; Homeopathy

Medicinal Functions:

Antibacterial; Antidepressant; Antirheumatic; Antispasmodic; Appetizer; Aromatherapy; Aromatic; Carminative; Digestive; Galactogogue; Ophthalmic; Stomachic; Tonic

Geographical Distribution:

Brazil; Israel; Italy; Mexico; Lebanon; Philippines; Indonesia; India; Rwanda; China; Kenya; Switzerland; Jordan; Argentina; Tanzania; Nigeria; Thailand

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Protein Kinase	MAPK1;
Transcription Factor	TP53;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP1A2; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.320E-10	1.775E-05	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.024E-08	7.433E-05	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	8.226E-08	4.478E-04	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	4.502E-07	1.634E-03	CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	6.563E-07	2.042E-03	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	9.002E-07	2.178E-03	CYP1A2, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	9.886E-06	1.493E-02	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.097E-05	1.493E-02	CYP1A2, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	1.554E-05	1.879E-02	CYP1A2, CYP2D6, CYP3A4
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	3.274E-04	1.478E-01	MAPK1, MAPT
CC	GO:0043226; organelle	GO:0016604; nuclear body	2.450E-03	3.580E-01	LMNA, MAPT, TP53
CC	GO:0044464; cell part	GO:0030424; axon	4.683E-03	4.552E-01	MAPK1, MAPT
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	5.052E-03	4.681E-01	CYP1A2, CYP2D6, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.174E-06	1.508E-04	CYP2D6, CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.579E-06	1.508E-04	CYP2D6, CYP1A2, CYP3A4
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.832E-05	7.146E-04	LMNA, MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.094E-04	1.904E-03	MAPK1, MAPT, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	5.654E-05	1.323E-03	MAPK1, TP53
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.654E-05	1.323E-03	CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	2.133E-04	2.383E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	1.838E-04	2.383E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.139E-04	1.904E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	2.876E-04	2.383E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	2.616E-04	2.383E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	2.965E-04	2.383E-03	MAPK1, TP53
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.289E-04	2.383E-03	CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	3.431E-04	2.497E-03	MAPK1, TP53
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.876E-04	2.383E-03	CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.056E-04	2.383E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	3.627E-04	2.497E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	5.388E-04	3.318E-03	MAPK1, TP53
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	8.513E-04	4.966E-03	CYP2D6, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	9.443E-04	4.966E-03	MAPK1, TP53
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	9.763E-04	4.966E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.576E-04	2.974E-03	CYP1A2, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.440E-03	6.739E-03	MAPK1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	1.197E-03	5.836E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	9.763E-04	4.966E-03	MAPK1, TP53
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.900E-03	8.549E-03	MAPK1, MAPT
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.999E-03	8.661E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; TP53;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases