Plant ID: NPO2038
Plant Latin Name: Myrtus tomentosa
Taxonomy Genus: Myrtus
Taxonomy Family: Myrtaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
GPBAR1; | |
NR1H4; | |
MAPT; LMNA; |
Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 9.649E-08 | 1.050E-03 | GPBAR1, NR1H4 |
MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 1.449E-03 | 5.547E-01 | NR1H4 |
CC | GO:0043226; organelle | GO:0016607; nuclear speck | 2.129E-03 | 5.795E-01 | LMNA, MAPT |
MF | GO:0005488; binding | GO:0034452; dynactin binding | 2.276E-03 | 6.110E-01 | MAPT |
MF | GO:0005488; binding | GO:0046965; retinoid X receptor binding | 3.103E-03 | 7.188E-01 | NR1H4 |
CC | GO:0044464; cell part | GO:0030673; axolemma | 3.309E-03 | 7.279E-01 | MAPT |
MF | GO:0005488; binding | GO:0034185; apolipoprotein binding | 3.309E-03 | 7.279E-01 | MAPT |
MF | GO:0005488; binding | GO:0016922; ligand-dependent nuclear receptor binding | 4.342E-03 | 8.012E-01 | NR1H4 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.472E-02 | 3.129E-02 | LMNA |
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.413E-02 | 3.129E-02 | NR1H4 |
09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.650E-02 | 3.129E-02 | LMNA |
09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.788E-02 | 3.129E-02 | LMNA |
09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.771E-02 | 3.871E-02 | LMNA |
09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 3.318E-02 | 3.871E-02 | MAPT |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 5.004E-02 | 5.004E-02 | MAPT |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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