CMAUP Plant Collective Molecular Activities

Plant Name: Gymnacranthera paniculata

Plant ID: NPO20329
Plant Latin Name: Gymnacranthera paniculata
Taxonomy Genus: Gymnacranthera
Taxonomy Family: Myristicaceae

NCBI TaxonomyDB: 1085445
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HCAR2;
Lyase	CA2; CA14; CA7; CA4; CA12; CA1; CA9;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.422E-07	3.096E-04	CA1, CA12, CA2, CA4, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.502E-07	8.912E-04	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.250E-06	3.266E-03	CA1, CA2
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	6.743E-06	9.177E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.588E-22	5.635E-18	CA1, CA12, CA14, CA2, CA4, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.539E-18	1.676E-14	CA1, CA12, CA14, CA2, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.546E-16	3.286E-12	CA1, CA12, CA2, CA4, CA7, CA9
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	1.168E-05	1.425E-02	CA2, CA7
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	4.748E-05	5.442E-02	CA2, CA4, CA9
CC	GO:0016020; membrane	GO:0005886; plasma membrane	2.537E-03	9.866E-01	CA12, CA14, CA2, CA4, CA9, HCAR2
CC	GO:0016020; membrane	GO:0031253; cell projection membrane	6.956E-03	1.000E+00	CA4, CA9
CC	GO:0044425; membrane part	GO:0031224; intrinsic component of membrane	3.728E-02	1.000E+00	CA12, CA14, CA4, CA9, HCAR2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.130E-22	4.291E-21	CA12, CA1, CA2, CA4, CA7, CA9, CA14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3.527E-05	1.235E-04	CA2, CA4
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	1.075E-02	2.509E-02	CA2
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	2.922E-02	4.091E-02	CA2
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.805E-02	4.091E-02	CA2
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	3.777E-02	4.406E-02	CA2
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	7.690E-02	7.690E-02	HCAR2

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases