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Plant Name: Mimosa pigra


Taxonomic Information:

Plant ID: NPO2030
Plant Latin Name: Mimosa pigra
Taxonomy Genus: Mimosa
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 367322
Plant-of-the-World-Online: 313003-2


Used in Medicines:

Country/Region:
Kenya; Tanzania; Rwanda; South Africa

Traditional Medicine System:


Geographical Distribution:

Brazil; Madagascar; Bangladesh; Kenya; Sudan; Guinea; Mali; Costa Rica; Cambodia; Malawi; Ethiopia; Rwanda; Trinidad and Tobago; Somalia; Suriname; Swaziland; Argentina; Bolivia; Cameroon; Burkina Faso; Ecuador; Benin; Ghana; Australia; Cuba; El Salvador; Zambia; Cote d'Ivoire; Togo; Guatemala; Zimbabwe; Germany; Vietnam; Thailand; Belize; Sierra Leone; Nigeria; Liberia; Uganda; Gambia; Tanzania; Mauritius; Paraguay; Mauritania; Uruguay; French Guiana; Guinea-Bissau; Guyana; Namibia; Taiwan; Jamaica; Angola; Myanmar; Chad; Mexico; Egypt; South Africa; Senegal; Congo; Mozambique; Colombia; Burundi; Gabon; Niger; Nicaragua; Botswana

Geographical Distribution
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−
See the Plant Occurrence Worldwide with Latitude and Longitude Available


Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Taste receptor (taste family GPCR)
TAS2R31;
Small molecule receptor (family A GPCR)
ADORA3;
Enzyme_unclassified
TDP1;
Potassium channels
KCNA3;
Nuclear hormone receptor subfamily 3 group A
ESR1;
ATP-binding cassette
ABCB1; ABCG2;
Unclassified
RAB9A; LMNA; NPC1; MAPT;
Methyl-lysine/arginine binding protein
SMN1;SMN2;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP1B1; CYP3A4; CYP1A1; CYP1A2; CYP2C19; CYP2C9; CYP19A1;

Detailed Information of Target Proteins

Protein ClassGene IDProtein NameUniprot IDTarget ChEMBL ID
ATP-binding cassette ABCB1 P-glycoprotein 1 P08183 CHEMBL4302
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 P08684 CHEMBL340
Enzyme_unclassified TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Showing 1 to 10 of 19 entries
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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO TypeGO CategoryEnriched GO Termsp-ValueAdjusted p-ValueEnriched Genes
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 1.739E-13 1.893E-09 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 1.252E-11 5.060E-08 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 1.394E-11 5.060E-08 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 4.114E-10 6.399E-07 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0070989; oxidative demethylation 2.076E-07 1.739E-04 CYP1A2, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0009404; toxin metabolic process 1.659E-06 1.129E-03 CYP1A1, CYP1A2, CYP1B1
BP GO:0008152; metabolic process GO:0006706; steroid catabolic process 2.431E-06 1.512E-03 CYP19A1, CYP1A2, CYP3A4
BP GO:0008152; metabolic process GO:0008209; androgen metabolic process 3.059E-06 1.800E-03 CYP19A1, CYP3A4, ESR1
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 6.104E-06 3.164E-03 CYP1A1, CYP1A2
BP GO:0008152; metabolic process GO:0002933; lipid hydroxylation 1.524E-05 6.914E-03 CYP1A1, CYP3A4
Showing 1 to 10 of 24 entries
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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)


Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways
Pathway Category Top LevelPathway Category Second LevelPathway IDPathway Namep-ValueAdjusted p-ValueEnriched Genes
09100 Metabolism 09103 Lipid metabolism hsa00140 Steroid hormone biosynthesis 2.578E-09 4.383E-08 CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09100 Metabolism 09111 Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 8.373E-09 9.490E-08 CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism 09103 Lipid metabolism hsa00591 Linoleic acid metabolism 1.699E-08 1.444E-07 CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism 09108 Metabolism of cofactors and vitamins hsa00830 Retinol metabolism 4.733E-07 3.219E-06 CYP2C9, CYP1A2, CYP1A1, CYP3A4
09100 Metabolism 09111 Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450 6.028E-07 3.416E-06 CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism 09105 Amino acid metabolism hsa00380 Tryptophan metabolism 8.252E-06 4.008E-05 CYP1A2, CYP1A1, CYP1B1
09100 Metabolism 09103 Lipid metabolism hsa00590 Arachidonic acid metabolism 1.733E-03 4.910E-03 CYP2C9, CYP2C19
09130 Environmental Information Processing 09131 Membrane transport hsa02010 ABC transporters 8.764E-04 2.980E-03 ABCB1, ABCG2
09150 Organismal Systems 09152 Endocrine system hsa04913 Ovarian steroidogenesis 1.627E-05 6.913E-05 CYP1A1, CYP1B1, CYP19A1
09150 Organismal Systems 09154 Digestive system hsa04976 Bile secretion 4.680E-05 1.768E-04 ABCB1, CYP3A4, ABCG2
Showing 1 to 10 of 12 entries
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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases
ICD10 Disease CategoryDisease NameICD10 CodeAssociated Disease Targets
(Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases Trematode infection B66.9 ESR1;
C00-D49: Neoplasms Advanced prostate cancer C61 ESR1;
C00-D49: Neoplasms Leukemia C90-C95 ESR1;
C00-D49: Neoplasms Prostate cancer C61 ESR1;
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 KCNA3;
C00-D49: Neoplasms Breast cancer C50 ESR1; CYP19A1;
C00-D49: Neoplasms Brain cancer C71, D33 ESR1;
C00-D49: Neoplasms Bladder cancer C67 CYP19A1;
C00-D49: Neoplasms Cancer C00-C96 ESR1;
C00-D49: Neoplasms Carcinoma D00-D09 ESR1;
Showing 1 to 10 of 50 entries
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Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
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