CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA1; CA5B; CA5A; CA6; CA12;
Unclassified	HTT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514

Showing 1 to 6 of 6 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.009E-13	1.098E-09	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.905E-13	2.108E-09	CA1, CA12, CA5A, CA5B, CA6
CC	GO:0044464; cell part	GO:0005770; late endosome	4.121E-02	1.000E+00	HTT
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.559E-07	1.829E-03	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.042E-16	1.751E-11	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0005488; binding	GO:0034452; dynactin binding	3.412E-03	1.000E+00	HTT

Showing 1 to 6 of 6 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.392E-15	2.785E-15	CA12, CA1, CA5B, CA5A, CA6
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05016	Huntington's disease	5.653E-02	5.653E-02	HTT

Showing 1 to 2 of 2 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Croton ruizianus

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities