Plant Name: Croton ruizianus
Taxonomic Information:
Plant ID: NPO20283
Plant Latin Name: Croton ruizianus
Taxonomy Genus: Croton
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
323079
Plant-of-the-World-Online:
70814-2
Used in Medicines:
Unknown.
Geographical Distribution:
Bolivia; Peru; Ecuador
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.009E-13 | 1.098E-09 | CA1, CA12, CA5A, CA5B, CA6 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 2.905E-13 | 2.108E-09 | CA1, CA12, CA5A, CA5B, CA6 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 7.559E-07 | 1.829E-03 | CA1, CA12, CA5A, CA5B, CA6 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 8.042E-16 | 1.751E-11 | CA1, CA12, CA5A, CA5B, CA6 |
| CC | GO:0044464; cell part | GO:0005770; late endosome | 4.121E-02 | 1.000E+00 | HTT |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 3.412E-03 | 1.000E+00 | HTT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 1.392E-15 | 2.785E-15 | CA12, CA1, CA5B, CA5A, CA6 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05016 | Huntington's disease | 5.653E-02 | 5.653E-02 | HTT |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
